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Clinical Chemistry 42: 1238-1242, 1996;
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Clinical Chemistry, Vol 42, 1238-1242, Copyright © 1996 by American Association for Clinical Chemistry

Determination of dexamethasone in saliva

JH Thijssen, CC Gispen-de Wied, GM van Heeswijk and W Veeman
Department of Endocrinology, University Hospital, Utrecht, The Netherlands. j.thijssen@lab.azu.nl

We conducted experiments to demonstrate that the determination of dexamethasone in saliva is a valuable tool to assess dexamethasone concentrations in the body after administration of this synthetic corticosteroid. After extraction of saliva, a RIA involving highly specific commercially available antibodies was established and evaluated. This RIA was easy to conduct, reliable, and sensitive enough to measure dexamethasone until approximately 24 h after oral administration of 1 mg per 70 kg of body weight. On the morning after the administration, the mean concentration in saliva was 540 pmol/L. Over a large range (10(3)-10(6) pmol/L), plasma concentrations correlated very well with salivary concentrations; plasma contained six times more dexamethasone than saliva.




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