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Clinical Chemistry 42: 1345-1349, 1996;
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Clinical Chemistry, Vol 42, 1345-1349, Copyright © 1996 by American Association for Clinical Chemistry

Evaluating the impact of exposure to environmental contaminants on human health [published erratum appears in Clin Chem 1997 Feb;43(2):410]

JB Silkworth and JF Brown Jr
General Electric Corporate R&D, Schenectady, NY 12301-0008, USA. Silkworth@crd.ge.com

Humans are exposed daily to low concentrations of many different chemical substances, natural and some man-made. Although many of these substances can be toxic at high levels, typical exposures are far below the effect levels. The responses produced by man-made aromatic hydrocarbon receptor agonists, such as dioxins, polychlorinated dibenzofurans, coplanar polychlorinated biphenyls, and polycyclic aromatic hydrocarbons, are also produced, often to greater extents [corrected], by naturally occurring constituents of fried meat, cabbage, broccoli, cauliflower, cocoa, and curry. Our society seems to be concerned about the health risks associated only with the synthetic chemicals, regardless of their proportional contribution to the total agonist activity, and regulates on the basis of such concerns. It would be more protective of the public health to determine acceptable concentrations for each type of response, regardless of the origin of the inducing agent, and issue advisories or regulations accordingly.





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