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Clinical Chemistry 42: 1506-1512, 1996;
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Clinical Chemistry, Vol 42, 1506-1512, Copyright © 1996 by American Association for Clinical Chemistry

Towards artificial antibodies prepared by molecular imprinting

RJ Ansell, O Ramstrom and K Mosbach
Department of Pure and Applied Biochemistry, Lund University, Center for Chemistry and Chemical Engineering, Sweden.

The new technique of molecular imprinting has increasingly been adopted by research laboratories worldwide during the last few years. We have studied the use of such imprints against drugs as artificial antibody- binding mimics in competitive radioimmuno-style binding assays. The recognition sites "molded" in the polymers mimic the binding sites of natural antibodies in their interactions with the target antigen. Binding constants are as low as 4.0 nmol/L for a small number of well- defined sites, and cross-reactivities are similar to or better than those observed with biological antibodies. In some cases, the polymers have been used to determine drug concentrations in human serum specimens.


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