Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 42: 1537-1541, 1996;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carville, D. G.
Right arrow Articles by Gargan, P. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carville, D. G.
Right arrow Articles by Gargan, P. E.

Clinical Chemistry, Vol 42, 1537-1541, Copyright © 1996 by American Association for Clinical Chemistry

Thrombus precursor protein (TpP): marker of thrombosis early in the pathogenesis of myocardial infarction

DG Carville, N Dimitrijevic, M Walsh, T Digirolamo, EM Brill, N Drew and PE Gargan
American Biogenetic Sciences & Lobund Laboratory, University of Notre Dame, IN., USA.

We have developed an enzyme-linked immunosorbent immunoassay for quantifying the immediate precursor proteins to intravascular thrombi. This thrombus precursor protein (TpP) assay identifies active thrombosis in several clinical conditions, including early myocardial infarction (MI). In a study of patients recruited for the GUSTO intervention study, MI patients had concentrations of TpP 4-20-fold that of controls; patients diagnosed without MI had concentrations similar to the control subjects. In a separate study of subjects presenting at the emergency room with chest pain, MI patients who presented early after the onset of chest pain had TpP concentrations significantly (P <0.01) higher than controls. Patients presenting late or diagnosed with other chest pain had concentrations within the reference range. The potential utility of the TpP assay as an aid for the diagnosis of thrombotic MI and other thrombotic conditions is described.


The following articles in journals at HighWire Press have cited this article:


Home page
 J Am Coll CardiolHome page
J. L. Mega, D. A. Morrow, J. A. de Lemos, S. Mohanavelu, C. P. Cannon, and M. S. Sabatine
Thrombus precursor protein and clinical outcomes in patients with acute coronary syndromes.
J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2422 - 2429.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
U. Derhaschnig, A. N. Laggner, M. Roggla, M. M. Hirschl, S. Kapiotis, C. Marsik, and B. Jilma
Evaluation of Coagulation Markers for Early Diagnosis of Acute Coronary Syndromes in the Emergency Room
Clin. Chem., November 1, 2002; 48(11): 1924 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
R. L. Bick
Disseminated Intravascular Coagulation: A Review of Etiology, Pathophysiology, Diagnosis, and Management: Guidelines for Care
Clinical and Applied Thrombosis/Hemostasis, January 1, 2002; 8(1): 1 - 31.
[PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Pernerstorfer, P. Stohlawetz, U. Hollenstein, L. Dzirlo, H.-G. Eichler, S. Kapiotis, B. Jilma, and W. Speiser
Endotoxin-Induced Activation of the Coagulation Cascade in Humans : Effect of Acetylsalicylic Acid and Acetaminophen
Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2517 - 2523.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. H.B. Wu, F. S. Apple, W. B. Gibler, R. L. Jesse, M. M. Warshaw, and R. Valdes Jr.
National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases
Clin. Chem., July 1, 1999; 45(7): 1104 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. T. Hermens, M. M. A. L. Pelsers, M.-L. Mullers-Boumans, C. de Zwaan, and J. F. C. Glatz
Combined Use of Markers of Muscle Necrosis and Fibrinogen Conversion in the Early Differentiation of Myocardial Infarction and Unstable Angina
Clin. Chem., April 1, 1998; 44(4): 890 - 892.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American Association for Clinical Chemistry.