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Clinical Chemistry 43: 141-145, 1997;
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(Clinical Chemistry. 1997;43:141-145.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Short-term and long-term variability of plasma homocysteine measurement

Uttam C. Garg1,a, Zhi-Jie Zheng2, Aaron R. Folsom2, Yvonne S. Moyer1, Michael Y. Tsai1, Paul McGovern2 and John H. Eckfeldt1

1 Department of Laboratory Medicine and Pathology, School of Medicine, and
2 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455.
a Address correspondence to this author, at: Box 609 Mayo, Department of Laboratory Medicine and Pathology, University of Minnesota Hospital and Clinics, Minneapolis, MN 55455. Fax 612-625-6994; e-mail gargx002{at}maroon.tc.umn.edu

Within-person and methodological variability of a given analyte are important elements in determining whether an individual has altered concentrations of that analyte. We report the short-term (1 month) within-person, between-person, and methodological variability of plasma homocysteine in 20 healthy participants from whom samples were drawn weekly for 4 weeks. The short-term between-person variance was high, whereas within-person and methodological variances were relatively very low, giving a high reliability coefficient (R) for homocysteine (R = 0.94). The long-term (30 months) reliability coefficient was 0.65, but was greatly influenced by an outlier (R = 0.82 with the outlier excluded). The data suggest that an individual's plasma homocysteine concentration is relatively constant over at least 1 month, and a single measurement characterizes the average concentration reasonably well.


Key Words: indexing terms: hyperhomocysteinemia • cardiovascular diseases • variation, source of • reliability coefficient




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