Clinical Chemistry
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Clinical Chemistry 43: 162-166, 1997;
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(Clinical Chemistry. 1997;43:162-166.)
© 1997 American Association for Clinical Chemistry, Inc.

Case Reports

A case of sulfhemoglobinemia and emergency measurement of sulfhemoglobin with an OSM3 CO-oximeter

Caicai Wu and Margaret A. Kennya

Department of Laboratory Medicine, Box 357110, School of Medicine, University of Washington, Seattle WA, 98195.
a Author for correspondence. Fax 206-548-6189; e-mail mkenny{at}u.washington.edu

We describe a case of sulfhemoglobinemia associated with toxic paint ingestion. Blood gases, oxygen content, and fractional hemoglobin derivatives were assayed with Radiometer 520 and OSM3 instruments. Although the CO-oximeters indicated the presence of sulfhemoglobin (SulfHb), the results were not quantitative. An OSM3 service software program was activated to obtain the actual concentrations of the hemoglobin fractions. Subsequently, we evaluated the performance of the OSM3 service program for the analysis of SulfHb by performing precision studies and comparing OSM3 results with those of an AVL 912 CO-oximeter. Retrospectively, we determined that the patient's specimens contained 6% SulfHb. There was an obvious deviation between standard OSM3 oxyhemoglobin fraction measurements and those obtained by using its service program—the effect of a high SulfHb content.


Key Words: indexing terms: blood gases • oxygen saturation • hemoglobin • toxicology




The following articles in journals at HighWire Press have cited this article:


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E. V. Sokurenko, V. Tchesnokova, A. T. Yeung, C. A. Oleykowski, E. Trintchina, K. T. Hughes, R. A. Rashid, J. M. Brint, S. L. Moseley, and S. Lory
Detection of simple mutations and polymorphisms in large genomic regions
Nucleic Acids Res., November 15, 2001; 29(22): e111 - e111.
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 Arch Pediatr Adolesc MedHome page
H. C. Lu, R. D. Shih, S. Marcus, B. Ruck, and T. Jennis
Pseudomethemoglobinemia: A Case Report and Review of Sulfhemoglobinemia
Arch Pediatr Adolesc Med, August 1, 1998; 152(8): 803 - 805.
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Copyright © 1997 by the American Association for Clinical Chemistry.