Clinical Chemistry
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Clinical Chemistry 43: 211-214, 1997;
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(Clinical Chemistry. 1997;43:211-214.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Standards of laboratory practice: evaluation of fetal lung maturity

Edward R. Ashwooda

Department of Pathology, University of Utah School of Medicine, and ARUP Laboratories, Inc., Salt Lake City, UT 84108.
a Address correspondence to: ARUP Laboratories, Inc., 500 Chipeta Way, Salt Lake City, UT 84108. Fax 801-584-5207; e-mail ashwood{at}med.utah.edu

In this standard of laboratory practice I recommend guidelines for fetal lung maturity (FLM) testing. If possible, obtain a 10-mL uncontaminated sample by amniocentesis. Keep the amniotic fluid at 4 °C and mix well before testing. If centrifugation is required, strictly adhere to the protocol. Most laboratories should offer a rapid test, such as fluorescence polarization, phosphatidylglycerol, or foam stability index, daily on both a routine and emergency basis. Requests for lecithin/sphingomyelin ratio may be referred to a reference laboratory. Communicate immediately the results of any FLM test to the ordering location. The report should contain the result, sample contamination, and reference information. Separate reference intervals for diabetic patients are not recommended.


Key Words: indexing terms: guidelines • fetal organ maturity • amniotic fluid chemistry • phosphatidylglycerol • lecithin/sphingomyelin ratio • fluorescence polarization




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
C. R. Fantz, C. Powell, B. Karon, C. A. Parvin, K. Hankins, M. Dayal, Y. Sadovsky, V. Johari, F. S. Apple, and A. M. Gronowski
Assessment of the Diagnostic Accuracy of the TDx-FLM II to Predict Fetal Lung Maturity
Clin. Chem., May 1, 2002; 48(5): 761 - 765.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.