Clinical Chemistry
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Clinical Chemistry 43: 222-227, 1997;
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(Clinical Chemistry. 1997;43:222-227.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Therapeutic drug monitoring principles in the neonate

Gideon Koren

Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada, and the University of Toronto, Toronto, Ontario, Canada.

Therapeutic drug monitoring in the newborn infant is necessary because dose requirements differ greatly from those for older children. These differences stem from major changes in kinetic disposition at the absorption, distribution, and elimination phases. The small blood volume of neonates makes them sensitive to iatrogenic blood loss. Similarly, the small size of these patients means that medication errors frequently lead to morbidity and even mortality. The clinical laboratory must set up strict, high-standard, carefully updated guidelines to ensure the safety of infants who need drug therapy at this very vulnerable phase of their lives.


Key Words: indexing terms: newborns • pharmacokinetics • drug administration




The following articles in journals at HighWire Press have cited this article:


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 PediatricsHome page
B. Magnani and R. Evans
Codeine Intoxication in the Neonate
Pediatrics, December 1, 1999; 104(6): 75e - 75.
[Abstract] [Full Text]

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 Clin. Chem.Home page
C. A. Hammett-Stabler and T. Johns
Laboratory guidelines for monitoring of antimicrobial drugs
Clin. Chem., May 1, 1998; 44(5): 1129 - 1140.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.