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Clinical Chemistry 43: 228-234, 1997;
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(Clinical Chemistry. 1997;43:228-234.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Assessing liver function and hyperbilirubinemia in the newborn

Philip Rosenthal

University of California, San Francisco Medical Center, 500 Parnassus Ave., MU 4-East, Box 0136, San Francisco, CA 94143-0136. Fax 415-476-1343; e-mail prosenth{at}peds.ucsf.edu

In clinical practice, "liver function" is assessed by either measuring the concentration of substances produced by the hepatocyte, measuring the serum content of substances that are changed by hepatocyte damage, evaluating the serum concentrations of substances released from the cells as a result of injury, assessing the ability of the liver to perform a metabolic task such as conjugation or detoxification, or by measuring enzyme activity and substrate content of the cell and its organelles. After birth, with cessation of placental function, the neonatal liver must assume many different tasks. Distinct developmental sequences rapidly progress for numerous hepatic functions as the newborn adapts to its environment. This manuscript is an attempt to provide guidelines for the evaluation and management of the newborn infant when assessing liver function and hyperbilirubinemia. These guidelines, like all sets of guidelines, are only recommendations and do not substitute for good clinical judgment based upon the individual circumstances of each patient.


Key Words: indexing terms: hepatic synthesis • coagulation • cholestasis




The following articles in journals at HighWire Press have cited this article:


Home page
 Br J AnaesthHome page
P. D. Booker, S. Gibbons, J. I. M. Stewart, A. Selby, E. Wilson-Smith, and M. Pozzi
Enoximone pharmacokinetics in infants
Br. J. Anaesth., August 1, 2000; 85(2): 205 - 210.
[Abstract] [Full Text] [PDF]

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 Pediatr. Rev.Home page
Laboratory Evaluation of Hepatitis
Pediatr. Rev., May 1, 2000; 21(5): 178 - 178.
[Full Text]


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