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Clinical Chemistry 43: 243-248, 1997;
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(Clinical Chemistry. 1997;43:243-248.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Use of the laboratory in prediction of outcome in the high-risk newborn

Anne R. Synnesa

The Department of Pediatrics, McGill University/Montreal Children's Hospital, Montreal, QC, Canada.
a Address correspondence to: 2300 Tupper St., C-920, Montreal, QC, Canada H3H 1P3. Fax 514-934-4356; e-mail asynnew{at}newborn.mchis.mcgill.ca

This paper reviews our ability to predict survival and neurodevelopmental outcome in the newborn period. Traditionally, prognosis is based on individual risk factors or disease states. The laboratory plays an important role in diagnosing some of these. For example, prenatal and newborn screening are important in the diagnosis of chromosomal abnormalities and inborn errors of metabolism. Abnormal bilirubin, glucose, and pH values in the newborn period are risk factors for death and abnormal neurodevelopment, and the degree of abnormality imparts additional information. Many newborns have multisystem disorders, and it is only when multiple variables are considered that outcome can be predicted. Three neonatal scores that incorporate multiple variables are discussed. Methodologic difficulties in determining outcome are reviewed and illustrated with survival and morbidity rates of very premature babies. The laboratory is one of many prognostic variables. The evaluation of how laboratory services are provided is difficult but important.


Key Words: indexing terms: neurodevelopment • mortality • severity of illness scores • low birth weight




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O. Hetland and K. Dickstein
Cardiac troponins I and T in patients with suspected acute coronary syndrome: a comparative study in a routine setting
Clin. Chem., July 1, 1998; 44(7): 1430 - 1436.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.