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Clinical Chemistry 43: 1850-1856, 1997;
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(Clinical Chemistry. 1997;43:1850-1856.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Combinations of ß chain abnormal hemoglobins with each other or with ß-thalassemia determinants with known mutations: influence on phenotype

Titus Hendrik and Jan Huisman

Department of Biochemistry and Molecular Biology, Research and Education Bldg., Room CB-2208, Medical College of Georgia, Augusta, GA 30912-2114. Fax 706-721-3092; e-mail research.acarver{at}mail.mcg.edu

Hematological and hemoglobin (Hb) data are presented for numerous patients with compound heterozygosities for different ß chain variants and for a ß chain variant with different ß-thalassemia (ß-thal) alleles. Considerable variations, which result from the type of ß chain variant and ß-thal mutation, can be noted. The comparison again emphasizes the importance of determining the diagnoses at the molecular level to aid the physician in the management of patients with different combinations of abnormalities. Simplification and commercialization of modern technology may make the introduction of this approach in some clinical chemistry laboratories possible.




The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
K. Zurbriggen, M. Schmugge, M. Schmid, S. Durka, P. Kleinert, T. Kuster, C. W. Heizmann, and H. Troxler
Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin. Chem., June 1, 2005; 51(6): 989 - 996.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
G. M. Clarke and T. N. Higgins
Laboratory Investigation of Hemoglobinopathies and Thalassemias: Review and Update
Clin. Chem., August 1, 2000; 46(8): 1284 - 1290.
[Abstract] [Full Text] [PDF]

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S. Dash and T. H. J. Huisman
Hb A2 in Subjects with Hb D • Reply.
Clin. Chem., November 1, 1998; 44(11): 2381 - 2382.
[Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.