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Significance of various parameters derived from biological variability of lipoprotein(a), homocysteine, cysteine, and total antioxidant status

Departments of
¹ Clinical Chemistry,
² Hematology, and
³ Internal Medicine III, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
⁴ Department of Epidemiology and Biostatistics, Erasmus University, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
^a Author for correspondence. Fax Int. +31–104367894; e-mail boersma{at}ckcl.azr.nl

Analytical and biological components of variability and various derived indices have been determined for lipoprotein(a) [Lp(a)], homocysteine (Hcy), cysteine (Cys), and total antioxidant status (TAOS) in ostensibly healthy adult Caucasians and in stable outpatients with an increased serum Lp(a). In healthy Caucasians, average intraindividual biological CVs (CV_b) were 20.0% for Lp(a), 9.4% for Hcy, 5.9% for Cys, and 2.8% for TAOS, CV_bs being similar in men and women. In the outpatient group, CV_bs were comparable for Hcy, Cys, and TAOS, but significantly lower for Lp(a) (7.5% vs 20.0%; P <0.0001). Moreover, a significant inverse relation between both biological and analytical CVs (CV_a) and serum Lp(a) concentrations was demonstrated. We conclude that average CV_a and CV_b values, and hence average derived indices, are adequate for Hcy, Cys, and TAOS, whereas individual values should be used for Lp(a).

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