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Test Utilization and Outcomes |
Departments of
1
Clinical Chemistry,
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Hematology, and
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Internal Medicine III, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
4
Department of Epidemiology and Biostatistics, Erasmus
University, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
a Author for correspondence. Fax Int. +31–104367894; e-mail boersma{at}ckcl.azr.nl
Analytical and biological components of variability and various derived indices have been determined for lipoprotein(a) [Lp(a)], homocysteine (Hcy), cysteine (Cys), and total antioxidant status (TAOS) in ostensibly healthy adult Caucasians and in stable outpatients with an increased serum Lp(a). In healthy Caucasians, average intraindividual biological CVs (CVb) were 20.0% for Lp(a), 9.4% for Hcy, 5.9% for Cys, and 2.8% for TAOS, CVbs being similar in men and women. In the outpatient group, CVbs were comparable for Hcy, Cys, and TAOS, but significantly lower for Lp(a) (7.5% vs 20.0%; P <0.0001). Moreover, a significant inverse relation between both biological and analytical CVs (CVa) and serum Lp(a) concentrations was demonstrated. We conclude that average CVa and CVb values, and hence average derived indices, are adequate for Hcy, Cys, and TAOS, whereas individual values should be used for Lp(a).
The following articles in journals at HighWire Press have cited this article:
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  L. R. Solomon Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing Blood, February 1, 2005; 105(3): 978 - 985. [Abstract] [Full Text] [PDF]
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 H. J. Huijgen, F. P.W. Tegelaers, C. H.H. Schoenmakers, C. J. Pronk-Admiraal, and S. Ekema Multicenter Analytical Evaluation of an Enzymatic Method for the Measurement of Plasma Homocysteine and Comparison with HPLC and Immunochemistry Clin. Chem., May 1, 2004; 50(5): 937 - 940. [Full Text] [PDF]
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M. R. Fokkema, M. F. Gilissen, J. J. van Doormaal, M. Volmer, I. P. Kema, and F. A.J. Muskiet Fasting vs Nonfasting Plasma Homocysteine Concentrations for Diagnosis of Hyperhomocysteinemia Clin. Chem., May 1, 2003; 49(5): 818 - 821. [Full Text] [PDF]
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 A. De Bree, W. M. M. Verschuren, D. Kromhout, L. A. J. Kluijtmans, and H. J. Blom Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease Pharmacol. Rev., December 1, 2002; 54(4): 599 - 618. [Abstract] [Full Text] [PDF]
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 E. Nurk, G. S. Tell, S. E. Vollset, O. Nygard, H. Refsum, and P. M. Ueland Plasma Total Homocysteine and Hospitalizations for Cardiovascular Disease: The Hordaland Homocysteine Study Arch Intern Med, June 24, 2002; 162(12): 1374 - 1381. [Abstract] [Full Text] [PDF]
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A. Voortman, A. Melse-Boonstra, J. M. Schulz, J. Burema, M. B. Katan, and P. Verhoef Optimal Time Interval between Repeated Blood Sampling for Measurements of Total Homocysteine in Healthy Individuals Clin. Chem., October 1, 2001; 47(10): 1839 - 1841. [Full Text] [PDF]
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M. C. McKinley, J.J. Strain, J. McPartlin, J. M. Scott, and H. McNulty Plasma Homocysteine Is Not Subject to Seasonal Variation Clin. Chem., August 1, 2001; 47(8): 1430 - 1436. [Abstract] [Full Text] [PDF]
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 T. Laskowska-Klita, E. Szymczak, and B. Radomyska Serum Homocysteine and Lipoprotein (a) Concentrations in Hypercholesterolemic and Normocholesterolemic Children Clinical Pediatrics, March 1, 2001; 40(3): 149 - 154. [Abstract] [PDF]
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K. Rasmussen, J. Moller, and M. Lyngbak Within-Person Variation of Plasma Homocysteine and Effects of Posture and Tourniquet Application Clin. Chem., October 1, 1999; 45(10): 1850 - 1855. [Abstract] [Full Text] [PDF]
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P. Thirup and S. Ekelund Day-to-Day, Postprandial, and Orthostatic Variation of Total Plasma Homocysteine Clin. Chem., August 1, 1999; 45(8): 1280 - 1283. [Full Text] [PDF]
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J. B. Ubbink, R. Delport, R. Riezler, and W.J. H. Vermaak Comparison of Three Different Plasma Homocysteine Assays with Gas Chromatography–Mass Spectrometry Clin. Chem., May 1, 1999; 45(5): 670 - 675. [Abstract] [Full Text] [PDF]
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E. Causse, N. Siri, H. Bellet, S. Champagne, C. Bayle, P. Valdiguie, R. Salvayre, and F. Couderc Plasma Homocysteine Determined by Capillary Electrophoresis with Laser-induced Fluorescence Detection Clin. Chem., March 1, 1999; 45(3): 412 - 414. [Full Text] [PDF]
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