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Clinical Chemistry 43: 2091-2098, 1997;
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(Clinical Chemistry. 1997;43:2091-2098.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Intramuscular administration of 5{alpha}-dihydrotestosterone heptanoate: changes in urinary hormone profile

Sarah B. Coutts1, Andrew T. Kicman1,a, Derek T. Hurst2 and David A. Cowan1

1 Drug Control Centre, King's College London, Manresa Rd., London SW3 6LX, UK.

2 School of Life Sciences, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK.
a Author for correspondence. Fax 44-171-351-2591; e-mail a.kicman{at}kcl ac.uk.

A recommended confirmatory procedure for detecting 5{alpha}-dihydrotestosterone (DHT) doping in male athletes proposed the use of the urinary concentration ratio of DHT to epitestosterone (EpiT) as the primary marker and those of 5{alpha}-androstane-3{alpha},17ß-diol (5{alpha}-Adiol) to EpiT, luteinizing hormone (LH), and 5ß-androstane-3{alpha},17ß-diol (5ß-Adiol) as secondary markers. Here we investigate the effects on these markers of intramuscular administration of DHT heptanoate (250 mg) to six healthy men. Within 24 h of administration all four markers greatly exceeded the published discrimination limits, remaining above these limits for 10–14 days. All ratios returned to basal values by day 28. In contrast to results after percutaneous administration, 5ß-Adiol excretion decreased, probably as a consequence of greater suppression of testicular steroidogenesis. Results were largely in agreement with those obtained after percutaneous administration, although probably augmented by the larger dose and the different route of delivery.




The following articles in journals at HighWire Press have cited this article:


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 Hum ReprodHome page
B.M. Brady, M. Walton, N. Hollow, A.T. Kicman, D.T. Baird, and R.A. Anderson
Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception
Hum. Reprod., November 1, 2004; 19(11): 2658 - 2667.
[Abstract] [Full Text] [PDF]

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 Sci SignalHome page
D. J. Handelsman
Designer Androgens in Sport: When Too Much Is Never Enough
Sci. Signal., August 3, 2004; 2004(244): pe41 - pe41.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
A. T. Kicman, J. K. Fallon, D. A. Cowan, C. Walker, S. Easmon, and D. Mackintosh
Candida albicans in Urine Can Produce Testosterone: Impact on the Testosterone/Epitestosterone Sports Drug Test
Clin. Chem., October 1, 2002; 48(10): 1799 - 1801.
[Full Text] [PDF]


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