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Clinical Chemistry 43: 2281-2291, 1997;
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(Clinical Chemistry. 1997;43:2281-2291.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry

John T. Bernert, Jr.a, Wayman E. Turner, James L. Pirkle, Connie S. Sosnoff, James R. Akins, Mary K. Waldrep, Qinghong Ann, Thomas R. Covey1, Wanda E. Whitfield, Elaine W. Gunter, Barbara B. Miller, Donald G. Patterson, Jr., Larry L. Needham, W. Harry Hannon and Eric J. Sampson

1 PE Sciex, 71 Four Valley Dr., Concord, Ontario L4K 4V8, Canada.
a Author for correspondence. Centers for Disease Control, Cham 17/2424 F-19, 4770 Buford Highway, NE, Atlanta, GA 30341-3724. Fax 770-488-4609; e-mail jtb2{at}cdc.gov

We describe a sensitive and specific method for measuring cotinine in serum by HPLC coupled to an atmospheric pressure chemical ionization tandem mass spectrometer. This method can analyze 100 samples/day on a routine basis, and its limit of detection of 50 ng/L makes it applicable to the analysis of samples from nonsmokers potentially exposed to environmental tobacco smoke. Analytical accuracy has been demonstrated from the analysis of NIST cotinine standards and from comparative analyses by both the current method and gas chromatography/high-resolution mass spectrometry. Precision has been examined through the repetitive analysis of a series of bench and blind QC materials. This method has been applied to the analysis of cotinine in serum samples collected as part of the Third National Health and Nutrition Examination Survey (NHANES III).




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