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Clinical Chemistry 43: 2303-2311, 1997;
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(Clinical Chemistry. 1997;43:2303-2311.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry

Chiung-Sheng Hsiung1, Joseph D. Andrade1, Robert Costa2 and K. Owen Ash2,a

1 Department of Materials Science & Engineering, University of Utah, Salt Lake City, UT 84112.

2 Department of Pathology and Associated Regional and University Pathologists, 500 Chipeta Way, Salt Lake City, UT 84108.
a Author for correspondence. Fax 801-583-2712; e-mail ASHKO{at}ARUP-lab.com

The determination of trace and ultratrace elements in biological fluids, including urine and serum, by inductively coupled plasma mass spectrometry (ICP-MS) is discussed. Nonspectral interferences and their corrections by external calibration and calibrator addition are discussed in detail. External calibration with internal calibration and dilution is mostly sufficient to correct for encountered biological matrix effects. For some elements, such as Cs and Zn, the use of calibrator addition provides more accurate results. The importance of spectral interferences and their elimination by isotope selection was also studied. Two examples, Cu and Zn, demonstrate the prime importance of selecting an isotope with minimal polyatomic interferences for analysis. By using 65Cu and 68Zn, accurate results for urine and serum can be obtained without excessive pretreatment of samples. Two reference materials, Bio-Rad Lyphochek urine and Kaulson Contox sera, were analyzed. Accuracy was evaluated by comparison with target values, and precision was estimated by the CV within 95% confidence.




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