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Clinical Chemistry 43: 2379-2383, 1997;
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(Clinical Chemistry. 1997;43:2379-2383.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Low plasma vitamin A concentrations in familial combined hyperlipidemia

Josep Ribalta, Agnes E. LaVille, Josefa Girona, Joan C. Vallvé and Lluís Masanaa

Unitat de Recerca de Lípids, Facultat de Medicina, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain.
a Author for correspondence. Fax (+34-77) 75 93 22; e-mail jrv{at}fmcs.urv.es

As many as 20% of the survivors of acute myocardial infarction present with the heritable form of hyperlipidemia, termed familial combined hyperlipidemia (FCHL). Some of the genes reported to be involved in this disorder, such as those for lipoprotein lipase (LPL) and apolipoprotein (apo) C-III, are controlled by a peroxisome proliferator-activated receptor (PPAR)/retinoic acid receptor X (RXR) regulatory system, which is retinoic acid dependent. If, as we hypothesized, the availability of retinoic acid or its precursor retinol (vitamin A) could be altered in FCHL, this could help explain some aspects of the phenotypic expression of the disease. We therefore measured plasma retinol concentrations in 30 FCHL subjects and 56 controls. Plasma retinol concentrations in FCHL subjects were significantly lower than that of control subjects (1.96 ± 0.83 µmol/L vs 2.91 ± 1.23 µmol/L, respectively; P <0.0001). This novel finding of significantly decreased concentrations of plasma retinol in FCHL relative to control subjects gives support to the hypothesis that vitamin A might be involved in the expression of this disorder.




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 J. Lipid Res.Home page
J. Ribalta, J. Girona, J. C. Vallvé, A. E. La Ville, M. Heras, and L. Masana
Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia
J. Lipid Res., March 1, 1999; 40(3): 426 - 431.
[Abstract] [Full Text]


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Copyright © 1997 by the American Association for Clinical Chemistry.