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Clinical Chemistry 43: 2397-2402, 1997;
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Right arrow Pediatric Clinical Chemistry
(Clinical Chemistry. 1997;43:2397-2402.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population

Nathalie Lepage, Nancy McDonald, Louis Dallaire and Marie Lamberta

Service de Génétique Médicale, Département de Pédiatrie, Hôpital Sainte-Justine and Université de Montréal, Montréal, QC, Canada.
a Address correspondence to this author at: Service de génétique médicale, Hôpital Ste-Justine, 3175 Côte Ste-Catherine, Montréal, QC, Canada H3T 1C5. Fax 514-345-4766; e-mail lamberma{at}ere.umontreal.ca

Reference values were determined for 23 plasma free amino acids from measurements done in 148 healthy children ranging from 0 to 18 years of age. Amino acid analysis was performed by ion-exchange chromatography. We propose a graphic form of presenting the age-specific distribution of plasma amino acid concentrations where the 10th, 50th, and 90th quantiles are illustrated. Although each amino acid possesses its own pattern of distribution, we can identify five different profiles. Nine amino acids (alanine, arginine, asparagine, methionine, ornithine, phenylalanine, proline, threonine, and tyrosine) demonstrate a decrease in their concentrations during the first year of life; their concentrations then tend to increase throughout childhood and adolescence. Nine others (cystine, glutamine, glycine, histidine, isoleucine, leucine, lysine, tryptophan, and valine) show a steady increase throughout infancy, childhood, and adolescence. Five amino acids (aspartic acid, citrulline, glutamic acid, serine, and taurine) do not follow these two common profiles. For the first time, quantile curves are produced to illustrate the age-dependent variation of amino acid concentrations from infancy to adulthood. This alternative way of presenting amino acid concentrations may facilitate the follow-up of patients with inborn errors of amino acid metabolism.




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Copyright © 1997 by the American Association for Clinical Chemistry.