Clinical Chemistry
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Clinical Chemistry 43: 2408-2412, 1997;
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(Clinical Chemistry. 1997;43:2408-2412.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum

Raymond Gambino1,a, Edouard Desvarieux1, Michael Orth2, Holly Matan3, Tomy Ackattupathil1, Elenore Lijoi1, Cathy Wimmer1, John Bower3 and Elaine Gunter4

1 Quest Diagnostics Inc., 1 Malcolm Ave., Teterboro, NJ 07608-1070;
2 Wallingford, CT 08492; and
3 Horsham, PA 19044.

4 Centers for Disease Control and Prevention, Atlanta, GA 30341.
a Author for correspondence. Fax 201-393-5903; e-mail Doclab{at}aol.com

We sought to determine if serum total iron-binding capacity (TIBC) is equivalent to serum transferrin (TRF) so that a low-cost colorimetric chemical assay for unsaturated iron-binding capacity (UIBC) could be substituted for a high-cost immunologic assay for TRF. Our study design included independent and blinded measurements of UIBC, serum iron, and TRF concentrations in human serum samples. Data from five independent correlation studies carried out at three different Quest Diagnostics laboratories were combined into one data set containing 570 paired results for TIBC and TRF. r2 was 0.941 when three outliers were eliminated from the 570-sample data set. Scatter about the regression line was fully accounted for by the CVs for the TIBC and TRF assays. When each test is measured precisely and without bias, the ratio of TIBC (µmol/L) to TRF (g/L) in SI units is close to the theoretically expected value of 25.0.




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Copyright © 1997 by the American Association for Clinical Chemistry.