Clinical Chemistry
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Clinical Chemistry 43: 285-289, 1997;
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(Clinical Chemistry. 1999;43:285-289.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Plasma and erythrocyte vitamin E content in asymptomatic hypercholesterolemic subjects

Emmanuelle Simon1, Jean-Louis Paul1,3,a, Théophile Soni1, Alain Simon2 and Nicole Moatti1,3

1 Laboratoire de Biochimie and
2 Centre de Médecine Préventive Cardiovasculaire, Hôpital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France.

3 Laboratoire de Biochimie Appliquée, Faculté des Sciences pharmaceutiques et biologiques, 92296 Châtenay-Malabry, France.
a Address correspondence to this author at: Laboratoire de Biochimie, Hôpital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France. Fax 33 (0) 1 45 41 35 13.

The present study was designed to assess plasma and erythrocyte vitamin E concentrations in 57 asymptomatic hypercholesterolemic (HC) men compared with 56 normocholesterolemic (NC) men. Vitamin E concentrations were determined by using a reversed-phase HPLC method. Compared with NC subjects, HC men had a significantly lower red blood cell (RBC) vitamin E content in spite of their normal plasma vitamin E concentration. This study demonstrates that total plasma vitamin E concentration is not a suitable predictor of cell vitamin E status and suggests an abnormal transfer of tocopherol between plasma and RBCs in HC men. Moreover, the RBCs of HC men were more susceptible to a peroxidative stress. The strong correlation between RBC susceptibility to oxidation and RBC vitamin E content suggests that the low RBC vitamin E content found in HC men has physiological consequences on the RBC oxidation.


Key Words: indexing terms: {alpha}-tocopherol • red blood cells • atherosclerosis • HPLC • antioxidants • peroxidative stress




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Nutr.Home page
W. L. Hall, Y. M. Jeanes, and J. K. Lodge
Hyperlipidemic Subjects Have Reduced Uptake of Newly Absorbed Vitamin E into Their Plasma Lipoproteins, Erythrocytes, Platelets, and Lymphocytes, as Studied by Deuterium-Labeled {alpha}-Tocopherol Biokinetics
J. Nutr., January 1, 2005; 135(1): 58 - 63.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.