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Clinical Chemistry 43: 369-378, 1997;
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(Clinical Chemistry. 1997;43:369-378.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Fluid elements—a concept for automation of diagnostic tests

Henk Van Damme, Thea Van Velthoven, Erik Kaelen and Eduard Pelssersa

Organon Teknika, Boseind 15, 5280 AB Boxtel, The Netherlands.
a Author for correspondence. Fax +31 411 654427; e-mail epelssers{at}am.otbc01.umc.akzonobel.nl

Constructs consisting of a channel, a membrane, and an absorber are designed for autonomously carrying out various liquid-handling functions of analytical tests. These so-called fluid elements can be used to set up various circuits for conducting several kinds of analytical tests. To demonstrate the feasibility of this concept, we constructed such a circuit and used it to perform, with two handling steps, an ELISA of hepatitis B surface antigen. The detection limit of the assay was comparable with those of state-of-the-art ELISAs for screening blood, and results could be obtained within a total test time of 20 min. We anticipate that this concept of automation may also serve as a basis for new, highly simplified immunoanalyzers.


Key Words: indexing terms: ELISA • hepatitis B surface antigen • immunoanalyzers




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
C. P. Price
The Evolution of Immunoassay as Seen Through the Journal Clinical Chemistry
Clin. Chem., October 1, 1998; 44(10): 2071 - 2074.
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