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Clinical Chemistry 43: 379-383, 1997;
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(Clinical Chemistry. 1999;43:379-383.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Optical tweezers-based immunosensor detects femtomolar concentrations of antigens

Kristian Helmerson1,a, Rani Kishore1, William D. Phillips1 and Howard H. Weetall2

1 Atomic Physics Division, and
2 Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
a Author for correspondence. Fax 301-975-3038; e-mail kristian{at}enh.nist.gov

We used optical tweezers (optical trapping technology) to measure the force required to separate antigen–antibody bonds. Under competitive-binding conditions, we used the force determination to detect and measure protein antigen concentrations as small as 1 fmol/L (10-15 mol/L).


Key Words: indexing terms: lasers • antigen–antibody binding • immunoassays






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