Clinical Chemistry
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Clinical Chemistry 43: 635-637, 1997;
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(Clinical Chemistry. 1997;43:635-637.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Interference with testing for lysergic acid diethylamide

Detlef Ritter1,2,a, Cherise M. Cortese2, Linda C. Edwards1, Judith L. Barr2, Hyung D. Chung1,2 and Christopher Long2

1 Pathology and Laboratory Medicine, 113JC, John Cochran Veterans Affairs Medical Center, 915 North Grand Blvd., Saint Louis, MO 63106.

2 Department of Pathology, Saint Louis University Health Sciences Center, 3635 Vista at Grand, P.O. Box 15250, Saint Louis, MO 63110-0250.
a Author for correspondence. Fax 314-268-5110; e-mail ritterdg{at}sluvca.slu.edu

We found a high rate (4.2%) of positive results for lysergic acid diethylamide (LSD) by Emit in 1898 urine samples that were submitted primarily from psychiatric patients for drugs-of-abuse (DOA) testing. Specimens that tested positive for LSD by Emit subsequently tested negative for LSD with two RIAs. Furthermore, LSD was not detected in randomly selected Emit-positive urine samples by gas chromatography–mass spectrometry. Normal urine samples tested positive for LSD by Emit when they were supplemented with therapeutic medications that were prescribed for patients with positive urine LSD results by Emit. These therapeutic drugs interfered specifically with the Emit assay for LSD, since other Emit DOA tests were not affected by these medications at the tested concentrations.


Key Words: indexing terms: LSD • immunoassay • drugs of abuse • drug monitoring • gas chromatography–mass spectrometry




The following articles in journals at HighWire Press have cited this article:


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M. D. Krasowski, M. G. Siam, M. Iyer, A. F. Pizon, S. Giannoutsos, and S. Ekins
Chemoinformatic Methods for Predicting Interference in Drug of Abuse/Toxicology Immunoassays
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 Psychiatr. Bull.Home page
A. J. Acosta-Armas
Problems encountered when testing for LSD in a regional medium secure unit
Psychiatr. Bull., January 1, 2003; 27(1): 17 - 19.
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G. Skopp, L. Potsch, R. Mattern, and R. Aderjan
Short-Term Stability of Lysergic Acid Diethylamide (LSD), N-Desmethyl-LSD, and 2-Oxo-3-hydroxy-LSD in Urine, Assessed by Liquid Chromatography-Tandem Mass Spectrometry
Clin. Chem., September 1, 2002; 48(9): 1615 - 1618.
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A. Gagajewski, G. K. Davis, J. Kloss, G. K. Poch, C. J. Anderson, and F. S. Apple
False-Positive Lysergic Acid Diethylamide Immunoassay Screen Associated with Fentanyl Medication
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Copyright © 1997 by the American Association for Clinical Chemistry.