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Review |
a Address correspondence to this author, at: Klinikum der Friedrich-Schiller-Universität Jena, Institut für Humangenetik und Anthropologie, Kollegiengasse 10, D-07740 Jena, Germany. Fax 03641-631713; e-mail rdah{at}mti-n.uni-jena.de
We review the present knowledge of telomeres and telomerase with special attention to their role in cell proliferation, cellular senescence, and human aging. We summarize the functional aspects of telomerase in cancer, as well as its role as a useful diagnostic and prognostic tumor marker, and discuss possible approaches to telomerase inhibition as a target for cancer therapy.
Key Words: indexing terms: cell regulation • aging • chromosomes • tumorigenesis
The following articles in journals at HighWire Press have cited this article:
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  Y.-L. Zheng, N. Hu, Q. Sun, C. Wang, and P. R. Taylor Telomere Attrition in Cancer Cells and Telomere Length in Tumor Stroma Cells Predict Chromosome Instability in Esophageal Squamous Cell Carcinoma: A Genome-Wide Analysis Cancer Res., February 15, 2009; 69(4): 1604 - 1614. [Abstract] [Full Text] [PDF]
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J. Shen, M. B. Terry, I. Gurvich, Y. Liao, R. T. Senie, and R. M. Santella Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets Cancer Res., June 1, 2007; 67(11): 5538 - 5544. [Abstract] [Full Text] [PDF]
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 J. Xu and X. Yang Telomerase Activity in Early Bovine Embryos Derived from Parthenogenetic Activation and Nuclear Transfer Biol Reprod, March 1, 2001; 64(3): 770 - 774. [Abstract] [Full Text]
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J. Xu and X. Yang Telomerase Activity in Bovine Embryos During Early Development Biol Reprod, October 1, 2000; 63(4): 1124 - 1128. [Abstract] [Full Text]
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 S. Gelmini, A. Crisci, B. Salvadori, M. Pazzagli, C. Selli, and C. Orlando Comparison of Telomerase Activity in Bladder Carcinoma and Exfoliated Cells Collected in Urine and Bladder Washings, Using a Quantitative Assay Clin. Cancer Res., July 1, 2000; 6(7): 2771 - 2776. [Abstract] [Full Text]
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I. Bièche, C. Noguès, V. Paradis, M. Olivi, P. Bedossa, R. Lidereau, and M. Vidaud Quantitation of hTERT Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay Clin. Cancer Res., February 1, 2000; 6(2): 452 - 459. [Abstract] [Full Text]
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T. C. Lavranos, J. M. Mathis, S. E. Latham, B. Kalionis, J. W. Shay, and R. J. Rodgers Evidence for Ovarian Granulosa Stem Cells: Telomerase Activity and Localization of the Telomerase Ribonucleic Acid Component in Bovine Ovarian Follicles Biol Reprod, August 1, 1999; 61(2): 358 - 366. [Abstract] [Full Text]
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Y. M. D. Lo Quantitative Assays for Telomerase: Means for Studying the End Clin. Chem., December 1, 1998; 44(12): 2399 - 2400. [Full Text] [PDF]
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S. Gelmini, A. Caldini, L. Becherini, S. Capaccioli, M. Pazzagli, and C. Orlando Rapid, quantitative nonisotopic assay for telomerase activity in human tumors Clin. Chem., October 1, 1998; 44(10): 2133 - 2138. [Abstract] [Full Text] [PDF]
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D. J. O'Kane, T. A. Ebert, B. J. Hallaway, S. G. Roberts, A. K. M. J. Bhuiyan, and K. S. Tenner A laboratorian's perspective on evaluation and implementation of new laboratory tests Clin. Chem., September 1, 1997; 43(9): 1771 - 1780. [Abstract] [Full Text] [PDF]
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