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Clinical Chemistry 43: 1023-1028, 1997;
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(Clinical Chemistry. 1997;43:1023-1028.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Gastrointestinal absorption, tissue retention, and urinary excretion of dietary aluminum in rats determined by using 26Al

Philippe Jouhanneau1, Grant M. Raisbeck1,a, Françoise Yiou1, Bernard Lacour2,3, Hélène Banide3 and Tilman B. Drüeke2

1 Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), CNRS-IN2P3, Bat 108, 91405 Orsay, France.

2 INSERM U 90, Hôpital Necker, Paris, France.

3 Département de Physiologie, Faculté de Pharmacie, Châtenay-Malabry, France.
a Author for correspondence. Fax 33 1 69 15 52 68; e-mail raisbeck{at}csnsm.in2p3.fr

We used accelerator mass spectrometry (AMS) and 26Al to study the plasma concentration, urinary excretion, and retention in bone, brain, and liver of a single dose of a dietary concentration of aluminum ingested either with or without citrate by 2-month-old Wistar rats. In the absence of citrate, cumulative urinary excretion and skeleton retention were each ~0.05% of the total 26Al dose ingested. 26Al retention in brain and liver were ~4 x 10-8 and 2 x 10-6, respectively. Concomitant citrate intake increased these median values by about two- to fivefold, although this factor was highly variable in individual rats. Independent of citrate administration, 90% of the26Al excreted in urine (measured cumulatively over 30 days) was excreted within the first 48 h. Uptake by bone was rapid (~1 h) and permanent over the 30-day duration of the experiment.


Key Words: indexing terms: mass spectrometry • rats • citrate • variation, source of • nutritional status • bone • brain • liver • toxicology




The following articles in journals at HighWire Press have cited this article:


Home page
 Toxicol SciHome page
R. A. Yokel, S. S. Rhineheimer, P. Sharma, D. Elmore, and P. J. McNamara
Entry, Half-Life, and Desferrioxamine-Accelerated Clearance of Brain Aluminum after a Single 26Al Exposure
Toxicol. Sci., November 1, 2001; 64(1): 77 - 82.
[Abstract] [Full Text] [PDF]


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