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Clinical Chemistry 43: 1033-1039, 1997;
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(Clinical Chemistry. 1997;43:1033-1039.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Evaluation of selected-ion storage ion-trap mass spectrometry for detecting urinary anabolic agents

Larry D. Bowersa and David J. Borts

Athletic Drug Testing and Toxicology Laboratory, Indiana University Medical Center, Medical Science Bldg. A-128, 635 Barnhill Dr., Indianapolis, IN 46202-5120.
a Author for correspondence. Fax 317-274-3223; e-mail lbowers{at}iupui.edu

Limits of detection are important issues for GC/MS screening for anabolic agents and for confirmation of various drugs of abuse. We compared a quadrupole ion trap (QIT) operated in two different selected-ion storage modes and a quadrupole mass filter (QMF) operated in the selected-ion monitoring mode. Results with the model compound tetrachlorobenzene indicate that, for simultaneous monitoring of more than four ions, the QIT operated in a frequency-modulated selected-ion storage mode has better limits of detection than the QMF. Use of a single-ion storage technique gave results similar to those of the QMF. We also evaluated both QIT selected-ion storage approaches for the limits of detection of the trimethylsilyl derivatives of four anabolic steroid metabolites and the ß-agonist clenbuterol. We found no improvement in detection limits over that of a similar method with selected-ion monitoring and a QMF when four anabolic steroid metabolites and clenbuterol were extracted from a urine matrix. The lack of improvement in the limit of detection resulted from matrix background signals at masses similar to those of the steroids.


Key Words: indexing terms: quadrupole ion trap • quadrupole mass filter • GC-MS • abused drugs • clenbuterol




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
L. D. Bowers
Analytical advances in detection of performance-enhancing compounds
Clin. Chem., July 1, 1997; 43(7): 1299 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. L. Fitzgerald, D. A. Herold, and A. L. Yergey
Trade-offs in Mass Spectrometry
Clin. Chem., June 1, 1997; 43(6): 915 - 915.
[Full Text] [PDF]


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