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Clinical Chemistry 43: 963-967, 1997;
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(Clinical Chemistry. 1997;43:963-967.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Free triiodothyronine concentration in serum of 1050 euthyroid children is inversely related to their age

Paul Verheecke

Centraal Laboratorium Hasselt, Elfde Liniestr. 27, B 3500 Hasselt, Belgium. Fax ++-3211–243291; e-mail paul.verheecke{at}club.innet.be

Free triiodothyronine was assayed in serum of 1050 euthyroid children with the Amerlex-MAB method. We studied 50 samples for each year of age, from <1 to 20, and no child had more than one sample taken. A gradient of values was observed, increasing by 31% from 5.04 pmol/L as the mean of 20-year-old patients to 6.59 pmol/L in the serum of children younger than 1 year. For practical reasons the lower normal limit was proposed to remain at 3.4 pmol/L for all patients; the higher limit can be set at 8.3 (0 to 3 years), 7.8 (4 to 7 years), 7.1 (8 to 11 years), 6.8 (12 to 15 years), and 6.7 (16 to 19 years). Preferably, the regression line of the mean + 2 SD can be used, resulting in a high normal limit of 8.3 pmol/L at birth to 6.3 pmol/L at 20 years, decreasing by 0.1 pmol/L per year.


Key Words: indexing terms: normal ranges • reference values






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