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Clinical Chemistry 43: 983-989, 1997;
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(Clinical Chemistry. 1997;43:983-989.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Semiautomated procedures for evaluation of carbohydrate-deficient transferrin in the diagnosis of alcohol abuse

Pamela Bean1,a, Karsten Liegmann1, Trond Løvli2, Christina Westby2 and Erling Sundrehagen2

1 Specialty Laboratories, Inc., Santa Monica, CA 90404-3900.

2 Axis Biochemicals, AS, Oslo, Norway.
a Author for correspondence. Fax 310-828-5173.

Carbohydrate-deficient transferrin (CDT) may now be the most valuable biological marker for diagnosis of alcohol abuse. We compared the diagnostic performance of two new CDT tests, Axis %CDT turbidimetric immunoassay (TIA) and Axis %CDT HPLC, against Specialty Laboratories' isoelectric focusing/immunoblotting/laser densitometry (IEF/IB/LD). Both Axis tests include one-half the concentration of trisialotransferrin isoforms in their CDT quantitation schemes. Considering an alcohol abuse prevalence of 7%, Axis %CDT TIA shows a sensitivity of 87% at 98% specificity and a positive predictive value (PPV) of 0.75; %CDT HPLC shows a sensitivity of 87% at 100% specificity for a PPV of 1, and the IEF/IB/LD shows 81% sensitivity at 94% specificity for a PPV of 0.5. All three CDT tests show the same negative predictive value (0.98). Both Axis procedures perform better than IEF/IB/LD in the diagnosis of alcohol abuse; %CDT TIA is available in several semiautomated, cost-effective formats.


Key Words: indexing terms: carbohydrate-deficient transferrin • alcohol abuse • diagnosis




The following articles in journals at HighWire Press have cited this article:


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L. M. Stadheim, J. F. O'Brien, K. D. Lindor, G. J. Gores, and D. B. McGill
Value of Determining Carbohydrate-Deficient Transferrin Isoforms in the Diagnosis of Alcoholic Liver Disease
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F. Tagliaro, F. Bortolotti, R. M. Dorizzi, M. Marigo, J. R. Delanghe, B. Wuyts, and M. L. De Buyzere
Caveats in Carbohydrate-deficient Transferrin Determination Drs. Delanghe, Wuyts, and De Buyzere respond:
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R. F. Anton, C. Dominick, M. Bigelow, and C. Westby
Comparison of Bio-Rad %CDT TIA and CDTect as Laboratory Markers of Heavy Alcohol Use and Their Relationships with {gamma}-Glutamyltransferase
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A. Helander, M. Fors, and B. Zakrisson
STUDY OF AXIS-SHIELD NEW %CDT IMMUNOASSAY FOR QUANTIFICATION OF CARBOHYDRATE-DEFICIENT TRANSFERRIN (CDT) IN SERUM
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J. M. Lacey, H. R. Bergen, M. J. Magera, S. Naylor, and J. F. O'Brien
Rapid Determination of Transferrin Isoforms by Immunoaffinity Liquid Chromatography and Electrospray Mass Spectrometry
Clin. Chem., March 1, 2001; 47(3): 513 - 518.
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B. Wuyts, J. R. Delanghe, I. Kasvosve, A. Wauters, H. Neels, and J. Janssens
Determination of Carbohydrate-deficient Transferrin Using Capillary Zone Electrophoresis
Clin. Chem., February 1, 2001; 47(2): 247 - 255.
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L. Dibbelt
Does Trisialo-Transferrin Provide Valuable Information for the Laboratory Diagnosis of Chronically Increased Alcohol Consumption by Determination of Carbohydrate-deficient Transferrin?
Clin. Chem., August 1, 2000; 46(8): 1203 - 1205.
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J. B. Whitfield, L. M. Fletcher, T. L. Murphy, L. W. Powell, J. Halliday, A. C. Heath, and N. G. Martin
Smoking, obesity, and hypertension alter the dose–response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake
Clin. Chem., December 1, 1998; 44(12): 2480 - 2489.
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K. Viitala, K. Lahdesmaki, and O. Niemela
Comparison of the Axis %CDT TIA and the CDTect method as laboratory tests of alcohol abuse
Clin. Chem., June 1, 1998; 44(6): 1209 - 1215.
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T. Arndt, R. Hackler, and P. Bean
Evaluation of Carbohydrate-deficient Transferrin Dr. Bean responds:
Clin. Chem., May 1, 1998; 44(5): 1069 - 1071.
[Full Text] [PDF]


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