Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 43: 990-995, 1997;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (34)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ricchiuti, V.
Right arrow Articles by Apple, F. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ricchiuti, V.
Right arrow Articles by Apple, F. S.
Related Collections
Right arrow Evidence Based Laboratory Medicine and Test Utilization
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 1997;43:990-995.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling

Vincent Ricchiuti1, Jianyi Zhang2 and Fred S. Apple1,a

1 Departments of Laboratory Medicine and Pathology and
2 Medicine, Hennepin County Medical Center and the University of Minnesota, Minneapolis, MN 55415.
a Author for correspondence, at: Hennepin County Medical Center, Clinical Labs MC 812, 701 Park Ave., Minneapolis, MN 55415. Fax 612-904-4229; e-mail fred.apple{at}co.hennepin.mn.us

Cardiac troponin T (cTnT) and troponin I (cTnI) have been suggested as new, more specific markers of myocardial cellular damage. The objective of this study was to examine how the distributions of cTnI and cTnT were affected in postinfarction left ventricular remodeled (LVR) myocardium. At 2 months postinfarct in a porcine heart failure model, both Western blot and biochemical assay analyses were performed on left ventricular myocardium remote from the infarct zone in ligation animals (n = 8). Results were compared with data from the left ventricular myocardium from similar sized healthy (control) pigs (n = 7). Autoradiograms from Western blot analysis showed that the protein mass for cTnI and cTnT in LVR hearts decreased 80% (P <0.001) and 40% (P <0.02), respectively, when compared with nondiseased tissue. Similarly, the concentrations for cTnI and cTnT in LVR hearts decreased 42% (P <0.05) and 70% (P <0.001), respectively, compared with nondiseased normal tissue. The clinical assumption is that the appearance of cTnI and cTnT in the blood is proportional to chronic loss of cTnI and cTnT from injured myocardium associated with left ventricular remodeling.


Key Words: indexing terms: heart disorders • animal models of disease • Western blot analysis • immunoassays




The following articles in journals at HighWire Press have cited this article:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Liu, J. Du, C. Zhang, J. W. Walker, and X. Huang
Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice
Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1273 - H1281.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. H. M. Hessel, P. Steendijk, B. den Adel, C. I. Schutte, and A. van der Laarse
Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2424 - H2430.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. A. Abbas, R. I. John, M. C. Webb, M. E. Kempson, A. N. Potter, C. P. Price, S. Vickery, and E. J. Lamb
Cardiac Troponins and Renal Function in Nondialysis Patients with Chronic Kidney Disease
Clin. Chem., November 1, 2005; 51(11): 2059 - 2066.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. van der Velden, D. Merkus, B.R. Klarenbeek, A.T. James, N.M. Boontje, D.H.W. Dekkers, G.J.M. Stienen, J.M.J. Lamers, and D.J. Duncker
Alterations in Myofilament Function Contribute to Left Ventricular Dysfunction in Pigs Early After Myocardial Infarction
Circ. Res., November 26, 2004; 95(11): e85 - e95.
[Abstract] [Full Text]

Home page
 J Am Coll CardiolHome page
W. P. Ingkanisorn, K. L. Rhoads, A. H. Aletras, P. Kellman, and A. E. Arai
Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarction
J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2253 - 2259.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. van der Laarse
Hypothesis: troponin degradation is one of the factors responsible for deterioration of left ventricular function in heart failure
Cardiovasc Res, October 1, 2002; 56(1): 8 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Murakami, J. Zhang, M. H. J. Eijgelshoven, W. Chen, W. C. Carlyle, Y. Zhang, G. Gong, and R. J. Bache
Myocardial creatine kinase kinetics in hearts with postinfarction left ventricular remodeling
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H892 - H900.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X. Huang, Y. Pi, K. J. Lee, A. S. Henkel, R. G. Gregg, P. A. Powers, and J. W. Walker
Cardiac Troponin I Gene Knockout : A Mouse Model of Myocardial Troponin I Deficiency
Circ. Res., January 22, 1999; 84(1): 1 - 8.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Association for Clinical Chemistry.