HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Alzeer, A. H. Articles by Yrkendi, M. S. Search for Related Content PubMed PubMed Citation Articles by Alzeer, A. H. Articles by Yrkendi, M. S.

Serum enzymes in heat stroke: prognostic implication

¹ Department of Medicine and
² Department of Biochemistry, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

³ Department of Medicine, King Faisal Hospital, Makkah, Saudi Arabia.
^a Address correspondence to this author at: King Khalid University Hospital, P.O. Box 18321, Riyadh 11415, Saudi Arabia. Fax (966) (1) 467-9495.

We measured serum creatine kinase (CK), lactate dehydrogenase (LD), aspartate aminotransferase (AST), and serum alanine aminotransferase (ALT) in 26 heat stroke (HS) victims and 10 control (non-heat-exhausted) subjects during annual Hajj in Makkah, Saudi Arabia. On admission to the HS treatment unit, serum CK, AST, ALT, and LD were higher in HS victims than controls (P <0.05), and at 6, 12, and 24 h were higher than baseline concentration. The patient group was divided into three groups, (a) those who had a quick recovery, (b) those who were critically ill until the end of the Hajj period (7 days), and (c) those who died. Serum enzymes at the time of admission were significantly higher (P <0.05) in the nonsurviving group (n = 6) and the severely ill (n = 9) than in those who had a quick recovery (n = 11). ROC curves were plotted for each enzyme. The most useful indicator was LD, as it could distinguish significantly between the groups who died and those who had a quick recovery (area under the curve = 0.991 ± 0.0286). It was followed by CK and AST as useful prognostic factors. When compared with ROC curves for body temperature, anion gap, and serum potassium, the enzyme results were superior prognostic indicators.

Key Words: indexing terms: creatine phosphokinase • lactate dehydrogenase • aspartate aminotransferase • alanine aminotransferase • receiver-operating characteristic plots

The following articles in journals at HighWire Press have cited this article:

				P. Brancaccio, N. Maffulli, and F. M. Limongelli Creatine kinase monitoring in sport medicine Br. Med. Bull., June 14, 2007; (2007) ldm014v1. [Abstract] [Full Text] [PDF]

				C. L. Lim, G. Wilson, L. Brown, J. S. Coombes, and L. T. Mackinnon Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R186 - R194. [Abstract] [Full Text] [PDF]

				H. Grogan and P. M. Hopkins Heat stroke: implications for critical care and anaesthesia Br. J. Anaesth., May 1, 2002; 88(5): 700 - 707. [Abstract] [Full Text] [PDF]