Clinical Chemistry
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Clinical Chemistry 43: 1196-1202, 1997;
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(Clinical Chemistry. 1997;43:1196-1202.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers

Cristine A. Costa1, Gilmar C. Trivelato2, Adriana M. P. Pinto3 and Etelvino J. H. Bechara3,a

1 Departamento de Toxicologia, Faculdade de Ciêancias Farmacêauticas da Universidade de São Paulo,
2 Fundação Jorge Duprat de Figueiredo e Medicina do Trabalho, Fundacentro, and
3 Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, 05599-970 São Paulo, SP, Brazil.
a Author for correspondence. Fax 5511-8155579; e-mail ebechara{at}quim.iq.usp.br

5-Aminolevulinic acid (ALA), a heme precursor accumulated in acute intermittent porphyria and lead poisoning, undergoes metal-catalyzed aerobic oxidation at physiological pH to yield reactive free radical species (O2-·>, HO·, and ALA·). We analyzed the relationships between plasma ALA concentrations, blood concentrations of lead, protoporphyrin IX (PP-IX), superoxide dismutase (SOD), and methemoglobin (metHb), and urine chemiluminescence (CL) in samples collected from lead-exposed workers. All variables measured were substantially (P <0.01) higher (2–8-fold) in the lead-exposed workers (n = 60). Plasma ALA concentrations were, on average, 6-fold higher in lead-exposed workers. We observed positive linear relationships between ALA and lead (r = 0.992), ALA and PP-IX (r = 0.891), ALA and metHb (r = 0.984), lead and SOD (r = 0.948), ALA and urine CL (r = 0.987), and lead and PP-IX (r = 0.993). These data are consistent with our free radical hypothesis for lead poisoning, where ALA distribution to and accumulation in several organs may trigger oxidative stress responses.


Key Words: indexing terms: : toxicology • lead • superoxide dismutase • protoporphyrin IX • methemoglobin • urine • chemiluminescence




The following articles in journals at HighWire Press have cited this article:


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 Hum Exp ToxicolHome page
M Ahamed, S Verma, A Kumar, and M K. Siddiqui
Delta-aminolevulinic acid dehydratase inhibition and oxidative stress in relation to blood lead among urban adolescents
Human and Experimental Toxicology, September 1, 2006; 25(9): 547 - 553.
[Abstract] [PDF]

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 Hum Exp ToxicolHome page
A B Engin, D Tuzun, and G Sahin
Evaluation of pteridine metabolism in battery workers chronically exposed to lead
Human and Experimental Toxicology, July 1, 2006; 25(7): 353 - 359.
[Abstract] [PDF]


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