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Clinical Chemistry 43: 1223-1231, 1997;
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(Clinical Chemistry. 1997;43:1223-1231.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Plasma protein abnormalities in nephrotic syndrome: effect on plasma colloid osmotic pressure and viscosity

Jorge Joven1,a, Xavier Clivillé1, Jordi Camps1, Eugenia Espinel2, Jose Simó1, Elisabet Vilella1 and Angel Oliver3

1 Centre de Recerca Biomedica. Unitat de Recerca Clínico Experimental, Hospital Universitari de Sant Joan/Facultad de Medicina de Reus, Universitat Rovira i Virgili. Calle Sant Joan s/n, 43201, Reus, Spain.

2 Hospital Valle de Hebrón, Barcelona, Spain.

3 Hospital Joan XXIII, Tarragona, Spain.
a Author for correspondence. Fax +3477312569; e-mail ala{at}fmcs.urv.es

The concentrations of 25 plasma proteins were measured in 22 patients with membranous nephropathy. For some large proteins, the plasma concentrations were increased; there were also large proteins with low plasma concentrations, but small or medium-sized proteins showed uniformly lower plasma concentration than the controls. Plasma colloid osmotic pressure ({pi}) and viscosity ({eta}) were not interrelated but showed positive and significant correlations with plasma concentrations of small and medium-sized proteins ({pi}) and plasma concentrations of large proteins ({eta}), respectively. Nephrotic plasma is not efficient in maintaining plasma {pi} but highly efficient in maintaining plasma {eta}. High plasma fibrinogen concentrations and low antithrombin III concentrations may predispose to thrombosis, and low IgG concentrations may account for the higher predisposition to bacterial infection. The relative composition of nephrotic plasma is heavily dependent on the size of the different proteins. Plasma {pi} and {eta} are also maintained by the relative preponderance of different plasma proteins.


Key Words: indexing terms: hypoalbuminemia • lipoproteins • membranous nephropathy • oncotic pressure • proteinuria • rheology






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Copyright © 1997 by the American Association for Clinical Chemistry.