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Clinical Chemistry 43: 1293-1298, 1997;
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(Clinical Chemistry. 1997;43:1293-1298.)
© 1997 American Association for Clinical Chemistry, Inc.

Doping in Sport Symposium Proceedings

Immunoprocedures for detecting human chorionic gonadotropin: clinical aspects and doping control

Ulf-Håkan Stenman1,a, Leila Unkila-Kallio2, Juha Korhonen2 and Henrik Alfthan1

Departments of
1 Clinical Chemistry and
2 Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN-00290 Helsinki, Finland.
a Author for correspondence. Fax +358-9-471 4804; e-mail ulf-hakan.stenman{at}hyks.mailnet.fi


Abstract

The pregnancy hormone human chorionic gonadotropin (hCG) is also present at low concentrations in plasma and urine of men and nonpregnant women. hCG immunoreactivity occurs in various molecular forms: Besides the intact hCG heterodimer, considerable amounts of proteolytically cleaved forms, free subunits, and fragments are found in plasma and urine. Especially in urine, proteolytic fragments constitute a major part of the hCG immunoreactivity. The different forms of hCG cross-react to various degrees in immunoassays and constitute a problem for standardization of specific hCG determinations. After injection of hCG (10 000 IU of Pregnyl®; Organon), above-normal concentrations of hCG can be detected in serum and urine for 7–11 days. Most immunoassays for hCG also measure hCGß. Quantitative hCG determinations are mainly performed on serum samples, and very few commercial hCG determinations have been validated for determination of urine samples. Considerable care must therefore be exercised when utilizing such assays to analyze urines for doping control.


Key Words: indexing terms: standardization • steroid hermones • urine • reference values • pregnancy • cancer • luteinizing hormone • estrogen




The following articles in journals at HighWire Press have cited this article:


Home page
 Hum Reprod UpdateHome page
U.-H. Stenman, A. Tiitinen, H. Alfthan, and L. Valmu
The classification, functions and clinical use of different isoforms of HCG
Hum. Reprod. Update, November 1, 2006; 12(6): 769 - 784.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
L. A. Cole, S. Shahabi, S. A. Butler, H. Mitchell, E. S. Newlands, H. R. Behrman, and H. L. Verrill
Utility of Commonly Used Commercial Human Chorionic Gonadotropin Immunoassays in the Diagnosis and Management of Trophoblastic Diseases
Clin. Chem., February 1, 2001; 47(2): 308 - 315.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
D. A. Cowan and A. T. Kicman
Doping in Sport: Misuse, Analytical Tests, and Legal Aspects
Clin. Chem., July 1, 1997; 43(7): 1110 - 1113.
[Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.