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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., Boston, MA 02111.
2
Pacific Biometrics Research Foundation, Seattle,
WA.
3
H.S. Raffaele, Milan, Italy.
4
Rotterdam University Hospital, Rotterdam, The
Netherlands.
5
Washington University School of Medicine, St.
Louis, MO.
6
State Laboratory of Hygiene, Madison, WI.
7
Osaka Medical Center for Cancer and Cardiovascular
Diseases, Osaka, Japan.
8
Institute of Biochemistry, Glasgow Royal Infirmary,
Glasgow, Scotland, UK.
9
Canadian Reference Laboratory (1996) Ltd.,
Vancouver, BC, Canada.
10
Centers for Disease Control and Prevention,
Atlanta, GA.
a Author for correspondence. Fax 617-556-3103;
Cholesterol and triglyceride standardization procedures have been used extensively and continuously since the 1950s. Definitive and Reference Methods, as well as primary and secondary standards, have been developed and maintained as the basis for evaluating the accuracy of results by various methods in many laboratories. But, although standardization efforts for apolipoprotein A-I and B measurements have been reported in detail in the scientific literature, much less has been reported in the area of total and lipoprotein cholesterol and triglyceride standardization efforts. Standardized cholesterol and triglyceride concentrations, determined in multiple large epidemiological and clinical studies, have been instrumental to the National Cholesterol Education Program panels that have assessed the lipoprotein values associated with risk of coronary disease, and have determined the cutpoints that are now used extensively by physicians to guide diagnosis and treatment of individual patients.
The following articles in journals at HighWire Press have cited this article:
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  L. M. Thienpont, K. Van Uytfanghe, J. Marriott, P. Stokes, L. Siekmann, A. Kessler, D. Bunk, and S. Tai Feasibility Study of the Use of Frozen Human Sera in Split-Sample Comparison of Immunoassays with Candidate Reference Measurement Procedures for Total Thyroxine and Total Triiodothyronine Measurements Clin. Chem., December 1, 2005; 51(12): 2303 - 2311. [Abstract] [Full Text] [PDF]
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L. M. Thienpont, K. Van Uytfanghe, J. Marriot, P. Stokes, L. Siekmann, A. Kessler, D. Bunk, and S. Tai Metrologic Traceability of Total Thyroxine Measurements in Human Serum: Efforts to Establish a Network of Reference Measurement Laboratories Clin. Chem., January 1, 2005; 51(1): 161 - 168. [Abstract] [Full Text] [PDF]
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 W. Richmond When and how to measure lipids and their role in CHD risk prediction The British Journal of Diabetes & Vascular Disease, May 1, 2003; 3(3): 191 - 198. [Abstract] [PDF]
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C. Cobbaert, C. Weykamp, H. Baadenhuijsen, A. Kuypers, J. Lindemans, and R. Jansen Selection, Preparation, and Characterization of Commutable Frozen Human Serum Pools as Potential Secondary Reference Materials for Lipid and Apolipoprotein Measurements: Study within the Framework of the Dutch Project "Calibration 2000" Clin. Chem., September 1, 2002; 48(9): 1526 - 1538. [Abstract] [Full Text] [PDF]
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C. M. Cobbaert and T. K. J. Luderer Total Error Evaluation of Roche Direct HDL-Cholesterol Reagent and Calibrator across 31 Lot Combinations: A 2-Year Experience Clin. Chem., January 1, 2000; 46(1): 133 - 134. [Full Text] [PDF]
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 A. Schlenck, B. Herbeth, G. Siest, and S. Visvikis Characterization and quantification of serum lipoprotein subfractions by capillary isotachophoresis: relationships with lipid, apolipoprotein, and lipoprotein levels J. Lipid Res., November 1, 1999; 40(11): 2125 - 2133. [Abstract] [Full Text]
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C. Cobbaert, P. G.H. Mulder, H. Baadenhuijsen, L. Zwang, C. W. Weykamp, and P. N.M. Demacker Survey of Total Error of Precipitation and Homogeneous HDL-Cholesterol Methods and Simultaneous Evaluation of Lyophilized Saccharose-containing Candidate Reference Materials for HDL-Cholesterol Clin. Chem., March 1, 1999; 45(3): 360 - 370. [Abstract] [Full Text] [PDF]
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