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Clinical Chemistry 43: 1357-1364, 1997;
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(Clinical Chemistry. 1997;43:1357-1364.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Increased alkaline phosphatase isoforms in autoimmune diseases

Atef N. Hanna1, W. James Waldman1, John A. Lott1,a, Stephen C. Koesters1, Anna M. Hughes2 and David J. Thornton2

1 Department of Pathology, The Ohio State University, Columbus, OH 43210.

2 Childrens Hospital, Department of Pathology, Columbus, OH 43215.
a Address correspondence to this author at: Starling Loving Hall M-368, O.S.U. Medical Center, 320 W. 10th Ave., Columbus, OH 43210-1240. Fax 614-293-5984; e-mail lott.1{at}osu.edu

We found significant increases in ALP and ALP isoform band 10 in the serum of patients with early insulin-dependent diabetes, rheumatoid arthritis, and in those with multiple sclerosis during periods of disease exacerbation as compared with healthy controls. The ALP isoforms were assayed by isoelectric focusing. Our data suggest that the increase in ALP and ALP-10 closely reflects the abnormal activation of T lymphocytes that is common in autoimmune diseases, and that the source of the ALP-10 is activated T lymphocytes. ALP-10 is a sensitive but nonspecific marker of an active autoimmune process and appears to have the ability to detect abnormal T-cell activation. ALP-10 may be a useful test in the screening for autoimmune disorders.






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Copyright © 1997 by the American Association for Clinical Chemistry.