| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
1
Department of Internal Medicine, Fujita Health University School of Medicine, 1–98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470–11, Japan.
2
Department of Clinical Chemistry, Fujita Health
University School of Health Sciences, Toyoake, Aichi, Japan
3
Third Division, Department of Internal Medicine, Osaka
Medical College, Takatsuki, Japan.
a Author for correspondence. Fax 81 562 93 2315; e-mail tkondo{at}fujita-hu.ac.jp
We compared the diagnostic utility of serum concentrations of human
heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin,
and their ratio for the early diagnosis of acute myocardial infarction
(AMI) in 104 healthy volunteers and 165 patients at admission within
6 h of the onset of chest pain. The ROC curves of the H-FABPc
[0.946, 95% confidence interval (CI) = 0.913–0.979] and myoglobin
(0.895, 95% CI = 0.846–0.944) between patients with AMI and
healthy volunteers were significantly greater than the area under the
ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.765–0.881). In
165 patients, the sensitivity (81.8%, 95% CI = 74.2–89.4%),
specificity (86.4%, 95% CI = 78.1–94.6%), and predictive
accuracy (83.6%, 95% CI = 78.0–89.3%) of H-FABPc >12 µg/L
in diagnosing AMI were significantly higher than those of myoglobin,
and were similar to those of the combination of H-FABPc >12 µg/L and
the ratio 
14. We conclude that H-FABPc is a more sensitive and
specific marker than myoglobin for the early diagnosis of AMI,
and that their ratio cannot give a clear advantage over the measurement
of H-FABPc alone.
Key Words: indexing terms: biochemical markers • myocardial injury
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  C. J. McCann, B. M. Glover, I. B.A. Menown, M. J. Moore, J. McEneny, C. G. Owens, B. Smith, P. C. Sharpe, I. S. Young, and J. A. Adgey Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T Eur. Heart J., August 5, 2008; (2008) ehn363v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. de Lemos and M. O'Donoghue The Skinny on Fatty Acid-Binding Protein J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2068 - 2070. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mad, H. Domanovits, C. Fazelnia, K. Stiassny, G. Russmuller, A. Cseh, G. Sodeck, T. Binder, G. Christ, T. Szekeres, et al. Human heart-type fatty-acid-binding protein as a point-of-care test in the early diagnosis of acute myocardial infarction QJM, April 1, 2007; 100(4): 203 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O'Donoghue, J. A. de Lemos, D. A. Morrow, S. A. Murphy, J. L. Buros, C. P. Cannon, and M. S. Sabatine Prognostic Utility of Heart-Type Fatty Acid Binding Protein in Patients With Acute Coronary Syndromes Circulation, August 8, 2006; 114(6): 550 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ishii, Y. Ozaki, J. Lu, F. Kitagawa, T. Kuno, T. Nakano, Y. Nakamura, H. Naruse, Y. Mori, S. Matsui, et al. Prognostic Value of Serum Concentration of Heart-Type Fatty Acid-Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome Clin. Chem., August 1, 2005; 51(8): 1397 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Sato, T Kita, Y Takatsu, and T Kimura Biochemical markers of myocyte injury in heart failure Heart, October 1, 2004; 90(10): 1110 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M.A.L. Pelsers, T. Hanhoff, D. Van der Voort, B. Arts, M. Peters, R. Ponds, A. Honig, W. Rudzinski, F. Spener, J. R. de Kruijk, et al. Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility Clin. Chem., September 1, 2004; 50(9): 1568 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.A. Alhadi and K.A.A. Fox Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein QJM, April 1, 2004; 97(4): 187 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M.A.L. Pelsers, A. Morovat, G. J.M. Alexander, W. T. Hermens, A. K. Trull, and J. F.C. Glatz Liver Fatty Acid-binding Protein as a Sensitive Serum Marker of Acute Hepatocellular Damage in Liver Transplant Recipients Clin. Chem., November 1, 2002; 48(11): 2055 - 2057. [Full Text] [PDF]
|
|
|
|
|
|
M J M de Groot, A M M Muijtjens, M L Simoons, W T Hermens, and J F C Glatz Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma Heart, March 1, 2001; 85(3): 278 - 285. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J.M. de Groot, K.W. H. Wodzig, M. L. Simoons, J. F.C. Glatz, and W. Th. Hermens Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates Cardiovasc Res, November 1, 1999; 44(2): 315 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M.A.L. Pelsers, J.-P. Chapelle, M. Knapen, C. Vermeer, A. M.M. Muijtjens, W. T. Hermens, and J. F.C. Glatz Influence of Age and Sex and Day-to-Day and Within-Day Biological Variation on Plasma Concentrations of Fatty Acid-binding Protein and Myoglobin in Healthy Subjects Clin. Chem., March 1, 1999; 45(3): 441 - 443. [Full Text] [PDF]
|
|
|
|
|
|
M. Robers, F. F. Van der Hulst, M. A. J. G. Fischer, W. Roos, C. E. Salud, H.-G. Eisenwiener, and J. F. C. Glatz Development of a Rapid Microparticle-enhanced Turbidimetric Immunoassay for Plasma Fatty Acid-binding Protein, an Early Marker of Acute Myocardial Infarction Clin. Chem., July 1, 1998; 44(7): 1564 - 1567. [Full Text] [PDF]
|
|
|
|
|
|
W. T. Hermens, M. M. A. L. Pelsers, M.-L. Mullers-Boumans, C. de Zwaan, and J. F. C. Glatz Combined Use of Markers of Muscle Necrosis and Fibrinogen Conversion in the Early Differentiation of Myocardial Infarction and Unstable Angina Clin. Chem., April 1, 1998; 44(4): 890 - 892. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
