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Clinical Chemistry 43: 1476-1486, 1997;
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(Clinical Chemistry. 1997;43:1476-1486.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Molecular biological methods in diagnosis and treatment of liver diseases

Howard J. Worman

Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., 10th Flr., Rm. 508, New York, NY 10032. Fax 212-305-6443; e-mail hjw14{at}columbia.edu

Molecular biology is making a tremendous impact on the diagnosis and treatment of liver diseases. Methods such as the polymerase chain reaction are changing the way physicians diagnose and monitor patients with viral hepatitis. Assays based on recombinant protein antigens allow for detection of specific autoantibodies in diseases such as primary biliary cirrhosis. The diagnosis of inherited metabolic diseases, such as hemochromatosis and Wilson disease, is being revolutionized by discovery of the defective genes involved and the development of methods to rapidly sequence DNA and identify mutations. Treatments and preventive measures are now possible with use of drugs and vaccines produced by recombinant DNA technology. Gene therapy and nucleic acid-based therapeutics are also realistic future treatment options for individuals with liver diseases.


Key Words: indexing terms: hepatitis • primary biliary cirrhosis • metabolic diseases • recombinant DNA • gene therapy






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Copyright © 1997 by the American Association for Clinical Chemistry.