Clinical Chemistry
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Clinical Chemistry 43: 1507-1511, 1997;
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(Clinical Chemistry. 1997;43:1507-1511.)
© 1997 American Association for Clinical Chemistry, Inc.

Articles

Hepatitis C—diagnosis and monitoring

Mickey S. Urdea2, Linda J. Wuestehube, Patricia M. Laurenson and Judith C. Wilber

Chiron Diagnostics, 4560 Horton St., Emeryville, CA 94608-2916.

Cloning of the hepatitis C virus (HCV) genome was a tremendous advance in the development of tests for diagnosis and monitoring of HCV-infected patients. Serological tests, including enzyme-linked immunoassays and RIBATM strip immunoblot assays, are primarily used to screen blood donations and to diagnose and confirm HCV infection. Tests for HCV RNA, including polymerase chain reaction (PCR)-based assays and the branched-DNA (bDNA) assay, are used for therapeutic monitoring and prognostics. Here, we present the development and future potential of these diagnostic tests. We also provide examples of how these tests are used to follow the progression of disease, select and adjust treatment protocols, and evaluate the efficacy of therapeutic regimens.




The following articles in journals at HighWire Press have cited this article:


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M. Chang, O. Williams, J. Mittler, A. Quintanilla, R. L. Carithers Jr., J. Perkins, L. Corey, and D. R. Gretch
Dynamics of Hepatitis C Virus Replication in Human Liver
Am. J. Pathol., August 1, 2003; 163(2): 433 - 444.
[Abstract] [Full Text] [PDF]

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 J. Clin. Microbiol.Home page
D. P. Kolk, J. Dockter, J. Linnen, M. Ho-Sing-Loy, K. Gillotte-Taylor, S. H. McDonough, L. Mimms, and C. Giachetti
Significant Closure of the Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Preseroconversion Detection Windows with a Transcription-Mediated-Amplification-Driven Assay
J. Clin. Microbiol., May 1, 2002; 40(5): 1761 - 1766.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.