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1
Department of Paediatric Biochemistry, Royal Hospital for Sick Children, Sciennes Rd., and Department of Child Life and Health, University of Edinburgh, 20 Sylvan Place, Edinburgh EH9 1LF, Scotland, UK.
2
Department of Paediatrics, Trinity College, Dublin and
the National Children's Hospital, Harcourt St., Dublin 2, Ireland.
3
Department of Zoology, Trinity College, Dublin 2,
Ireland.
a Author for correspondence. Fax 44-131-5360410.
We report pediatric age- and sex-specific 95% reference intervals for
procollagen type I C-terminal propeptide (PICP), the cross-linked
C-terminal telopeptide of type I collagen (ICTP), and procollagen type
III N-terminal propeptide (P3NP), measured in plasma from 302
schoolchildren (156 boys, 146 girls) ages 4–19 years. All three
markers displayed a significant variation with age (ANOVA P
0.0015). PICP showed no detectable increase during adolescence for
either sex, but decreased towards adult concentrations after the age of
puberty, with an earlier decrease for girls than for boys
(P <0.01). ICTP and P3NP both increased in pubertal-aged
children (P <0.05), with an earlier increase in girls than
in boys (P <0.05), before decreasing towards adult
concentrations (P <0.01). All three collagen markers were
highly correlated with one another (P <0.001). The
patterns observed mirrored the childhood growth curve and reflected the
high turnover of bone and soft tissue during childhood
growth.
The following articles in journals at HighWire Press have cited this article:
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