HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (35) Citing Articles via Google Scholar Google Scholar Articles by Crofton, P. M. Articles by Holland, C. V. Search for Related Content PubMed PubMed Citation Articles by Crofton, P. M. Articles by Holland, C. V. Related Collections Pediatric Clinical Chemistry Proteomics and Protein Markers Endocrinology and Metabolism

Serum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxyl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren

¹ Department of Paediatric Biochemistry, Royal Hospital for Sick Children, Sciennes Rd., and Department of Child Life and Health, University of Edinburgh, 20 Sylvan Place, Edinburgh EH9 1LF, Scotland, UK.

² Department of Paediatrics, Trinity College, Dublin and the National Children's Hospital, Harcourt St., Dublin 2, Ireland.

³ Department of Zoology, Trinity College, Dublin 2, Ireland.
^a Author for correspondence. Fax 44-131-5360410.

We report pediatric age- and sex-specific 95% reference intervals for procollagen type I C-terminal propeptide (PICP), the cross-linked C-terminal telopeptide of type I collagen (ICTP), and procollagen type III N-terminal propeptide (P3NP), measured in plasma from 302 schoolchildren (156 boys, 146 girls) ages 4–19 years. All three markers displayed a significant variation with age (ANOVA P 0.0015). PICP showed no detectable increase during adolescence for either sex, but decreased towards adult concentrations after the age of puberty, with an earlier decrease for girls than for boys (P <0.01). ICTP and P3NP both increased in pubertal-aged children (P <0.05), with an earlier increase in girls than in boys (P <0.05), before decreasing towards adult concentrations (P <0.01). All three collagen markers were highly correlated with one another (P <0.001). The patterns observed mirrored the childhood growth curve and reflected the high turnover of bone and soft tissue during childhood growth.

The following articles in journals at HighWire Press have cited this article:

				J. Leger, I. Mercat, C. Alberti, D. Chevenne, P. Armoogum, J. Tichet, and P. Czernichow The relationship between the GH/IGF-I axis and serum markers of bone turnover metabolism in healthy children Eur. J. Endocrinol., November 1, 2007; 157(5): 685 - 692. [Abstract] [Full Text] [PDF]

				M. Rauchenzauner, A. Schmid, P. Heinz-Erian, K. Kapelari, G. Falkensammer, A. Griesmacher, G. Finkenstedt, and W. Hogler Sex- and Age-Specific Reference Curves for Serum Markers of Bone Turnover in Healthy Children from 2 Months to 18 Years J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 443 - 449. [Abstract] [Full Text] [PDF]

				J. D. Ahn, B. Dubern, C. Lubrano-Berthelier, K. Clement, and G. Karsenty Cart Overexpression Is the Only Identifiable Cause of High Bone Mass in Melanocortin 4 Receptor Deficiency Endocrinology, July 1, 2006; 147(7): 3196 - 3202. [Abstract] [Full Text] [PDF]

				R. Eastell Role of oestrogen in the regulation of bone turnover at the menarche J. Endocrinol., May 1, 2005; 185(2): 223 - 234. [Abstract] [Full Text] [PDF]

				P. M. Crofton, N. Evans, M. R.H. Taylor, and C. V. Holland Procollagen Type I Amino-Terminal Propeptide: Pediatric Reference Data and Relationship with Procollagen Type I Carboxyl-Terminal Propeptide Clin. Chem., November 1, 2004; 50(11): 2173 - 2176. [Full Text] [PDF]

				P. M. Crofton, N. Evans, M. R.H. Taylor, and C. V. Holland Serum CrossLaps: Pediatric Reference Intervals from Birth to 19 Years of Age Clin. Chem., April 1, 2002; 48(4): 671 - 673. [Full Text] [PDF]

				C. Heuck, L. Heickendorff, and O. D Wolthers A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide Arch. Dis. Child., October 1, 2000; 83(4): 334 - 339. [Abstract] [Full Text] [PDF]

				P. Arikoski, J. Komulainen, P. Riikonen, R. Voutilainen, M. Knip, and H. Kröger Alterations in Bone Turnover and Impaired Development of Bone Mineral Density in Newly Diagnosed Children with Cancer: A 1-Year Prospective Study J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3174 - 3181. [Abstract] [Full Text]

				K.-S. Tsai, M.-H. Jang, S. H.-J. Hsu, W.-C. Cheng, and M.-H. Chang Bone Alkaline Phosphatase Isoenzyme and Carboxy-Terminal Propeptide of Type-I Procollagen in Healthy Chinese Girls and Boys Clin. Chem., January 1, 1999; 45(1): 136 - 138. [Full Text] [PDF]

				P. M. Crofton, S. F. Ahmed, J. C. Wade, R. Stephen, M. W. Elmlinger, M. B. Ranke, C. J. H. Kelnar, and W. H. B. Wallace Effects of Intensive Chemotherapy on Bone and Collagen Turnover and the Growth Hormone Axis in Children with Acute Lymphoblastic Leukemia J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3121 - 3129. [Abstract] [Full Text]