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Central Laboratory
1 Department of Clinical Chemistry
2 Department of Hematology, University
Hospital of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland
a Author for correspondence; Fax 358-02-2613920;
During the last few years the measurement of serum-soluble transferrin receptor (sTfR) has been introduced as a tool to detect iron deficiency and as an analyte to differentiate between anemia caused by iron deficiency (IDA) and that caused by chronic disease (ACD). Commercially available methods have emerged to make diagnostics by sTfR more readily accessible. We documented the analytical performance of a newly introduced IDeATM sTfR immunoenzymometric assay (IEMA) by Orion Diagnostica. We also evaluated its clinical performance in 98 consecutive anemic patients, with information derived from bone marrow aspirate samples as the reference for iron status. The clinical usefulness of two other commercially available sTfR assays was assessed for comparison. The analytical performance and clinical applicability of the IDeA were sufficient to support reliable clinical work. We conclude that IDA and iron deficiency in the presence of inflammatory states can be differentiated efficiently from ACD with this new commercial test to measure sTfR.
The following articles in journals at HighWire Press have cited this article:
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  R. Vikstedt, P. von Lode, T. Takala, K. Irjala, O. Peltola, K. Pettersson, and P. Suominen Rapid One-Step Immunofluorometric Assay for Measuring Soluble Transferrin Receptor in Whole Blood Clin. Chem., October 1, 2004; 50(10): 1831 - 1833. [Full Text] [PDF]
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 P. Halonen, J. Mattila, P. Suominen, T. Ruuska, M. K. Salo, and A. Makipernaa Iron Overload in Children Who Are Treated for Acute Lymphoblastic Leukemia Estimated by Liver Siderosis and Serum Iron Parameters Pediatrics, January 1, 2003; 111(1): 91 - 96. [Abstract] [Full Text] [PDF]
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 F. S. Asobayire, P. Adou, L. Davidsson, J. D Cook, and R. F Hurrell Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Cote dIvoire Am. J. Clinical Nutrition, December 1, 2001; 74(6): 776 - 782. [Abstract] [Full Text]
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G. Van den Bosch, J. Van den Bossche, C. Wagner, P. De Schouwer, M. Van De Vyvere, and H. Neels Determination of Iron Metabolism-related Reference Values in a Healthy Adult Population Clin. Chem., August 1, 2001; 47(8): 1465 - 1467. [Full Text] [PDF]
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P. Suominen, A. Virtanen, M. Lehtonen-Veromaa, O. J. Heinonen, T. T. Salmi, M. Alanen, T. Mottonen, A. Rajamaki, and K. Irjala Regression-based Reference Limits for Serum Transferrin Receptor in Children 6 Months to 16 Years of Age Clin. Chem., May 1, 2001; 47(5): 935 - 937. [Full Text] [PDF]
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M. Olivares, T. Walter, J. D Cook, E. Hertrampf, and F. Pizarro Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy Am. J. Clinical Nutrition, November 1, 2000; 72(5): 1191 - 1195. [Abstract] [Full Text] [PDF]
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 L. T. Goodnough, B. Skikne, and C. Brugnara Erythropoietin, iron, and erythropoiesis Blood, August 1, 2000; 96(3): 823 - 833. [Abstract] [Full Text] [PDF]
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E. J. Harthoorn-Lasthuizen, P. vant Sant, J. Lindemans, and M. M.A.C. Langenhuijsen Serum Transferrin Receptor and Erythrocyte Zinc Protoporphyrin in Patients with Anemia, Clin. Chem., May 1, 2000; 46(5): 719 - 722. [Full Text] [PDF]
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J. W. Choi, S. H. Pai, M. W. Im, and S. K. Kim Change in Transferrin Receptor Concentrations with Age Clin. Chem., September 1, 1999; 45(9): 1562 - 1563. [Full Text] [PDF]
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P. Suominen, K. Punnonen, A. Rajamaki, R. Majuri, V. Hanninen, and K. Irjala Automated Immunoturbidimetric Method for Measuring Serum Transferrin Receptor Clin. Chem., August 1, 1999; 45(8): 1302 - 1305. [Full Text] [PDF]
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 C. Brugnara, D. Zurakowski, J. DiCanzio, T. Boyd, and O. Platt Reticulocyte Hemoglobin Content to Diagnose Iron Deficiency in Children JAMA, June 16, 1999; 281(23): 2225 - 2230. [Abstract] [Full Text] [PDF]
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P. Suominen, K. Punnonen, A. Rajamaki, and K. Irjala Serum Transferrin Receptor and Transferrin Receptor-Ferritin Index Identify Healthy Subjects With Subclinical Iron Deficits Blood, October 15, 1998; 92(8): 2934 - 2939. [Abstract] [Full Text] [PDF]
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B. S. Skikne Circulating Transferrin Receptor Assay—Coming of Age Clin. Chem., January 1, 1998; 44(1): 7 - 9. [Full Text] [PDF]
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