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Clinical Chemistry 43: 1697-1702, 1997;
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(Clinical Chemistry. 1997;43:1697-1702.)
© 1997 American Association for Clinical Chemistry, Inc.

Oak Ridge Conference

Point-of-care fibrinolytic tests: the other side of blood coagulation

Bruce J. Oberhardt1,a, Patrick D. Mize2 and Cynthia G. Pritchard2

1 Sanguinex, P.O. Box 98385, Raleigh, NC 27624-8685.

2 Cardiovascular Diagnostics, Inc., 5301 Departure Dr., Raleigh, NC 27616.
a Author for correspondence. Fax 919-676-5436; e-mail bjo{at}ntwrks.com


Abstract

Point-of-care (POC) coagulation tests with paramagnetic iron oxide particles have provided alternatives to testing previously done only in the laboratory. With this technology, POC fibrinolytic tests have followed quietly the trail blazed by POC clotting tests and have found specific applications. These include rapid verification of in vivo thrombolytic drug action by in vitro testing with subsequent quantitative drug monitoring of the systemic lytic state, and also the determination of in vitro thrombolytic drug response before the drug is actually administered, to individualize therapy by selection of the most appropriate drug. Other applications include POC coagulation factor assays associated with fibrinolysis, and most recently the POC screening of patients with fibrinolytic defects. In this latter application, plasma from cardiac catheterization (n = 19) and venous thrombosis (n = 47) patient groups were tested. Controls consisted of two independent donor pools (n = 10, n = 21) as negatives and two plasma samples with known genetic defects in the fibrinogen molecule (A{alpha}554 Arg -> Cys) as positives.




The following articles in journals at HighWire Press have cited this article:


Home page
 CLIN APPL THROMB HEMOSTHome page
T. W. Stief and J. Fareed
Point of Care: Diagnostics in Hemostasisthe Wrong Direction?
Clinical and Applied Thrombosis/Hemostasis, July 1, 2003; 9(3): 191 - 195.
[Abstract] [PDF]


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Copyright © 1997 by the American Association for Clinical Chemistry.