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Clinical Chemistry 43: 1724-1731, 1997;
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(Clinical Chemistry. 1997;43:1724-1731.)
© 1997 American Association for Clinical Chemistry, Inc.

Oak Ridge Conference

Blood substitutes: evolution and future applications

Mitchell G. Scott, Dennis F. Kucik, Lawrence T. Goodnough and Terri G. Monka

a Author for correspondence. Fax 314-747-1716; e-mail monkt{at}notes.wustl.edu


Abstract

The development of oxygen-carrying blood substitutes has progressed significantly in the last decade with phase I and phase II clinical trials of both hemoglobin-based and perfluorocarbon-based oxygen carriers nearing completion. As these products approach clinical use it is important for the laboratory medicine community to be aware of their effects on routine laboratory testing and the settings in which they might be used. Here we review the forces driving the development of oxygen-carrying blood substitutes, the clinical settings in which they might be used, the major categories of oxygen carriers in clinical trials, and the challenges faced by these products as they approach clinical use.




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