|
|
||||||||
Oak Ridge Conference |
a Author for correspondence: fax 416-798-0152.
Abstract
The interferences of o-raffinose cross-linked hemoglobin
(HemolinkTM) were examined and compared in two
serum creatinine methods on the Hitachi 717 [Boehringer Mannheim
(BMC) and Synermed] and in an enzymatic creatinine method on the
Vitros 750 (Johnson & Johnson). Interference was considered significant
when the change in creatinine concentration from the control exceeded
the 95% confidence limits of each method. Significant interference was
observed for the BMC/Hitachi 717 method with Hemolink
5 g/L. No
interference was observed for the Synermed/Hitachi 717 assay with
Hemolink up to 30 g/L in normal samples and up to 50 g/L in samples
with increased creatinine. No interference was observed for the Vitros
750 assay with Hemolink up to 50 g/L at both normal and increased
concentrations of creatinine. Although the BMC/Hitachi 717 method was
considered unacceptable, the Synermed/Hitachi 717 and the Vitros 750
methods allow accurate quantification of serum creatinine in the
presence of Hemolink.
The following articles in journals at HighWire Press have cited this article:
![]() |
G. L. Myers, W. G. Miller, J. Coresh, J. Fleming, N. Greenberg, T. Greene, T. Hostetter, A. S. Levey, M. Panteghini, M. Welch, et al. Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program Clin. Chem., January 1, 2006; 52(1): 5 - 18. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A. Ali, G. S. Ali, J. M. Steinke, and A. P. Shepherd Co-Oximetry Interference by Hemoglobin-Based Blood Substitutes Anesth. Analg., April 1, 2001; 92(4): 863 - 869. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Balion, P. A. Champagne, and A. C. Y. Ali Evaluation of HemogloBindTM for Removal of o-Raffinose Cross-Linked Hemoglobin (HemolinkTM) from Serum Clin. Chem., September 1, 1997; 43(9): 1796 - 1798. [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |