| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Test Utilization and Outcomes |
1
Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford, OX2 6HE, UK.
2
Department of Clinical Gerontology, Addenbrooke's
Hospital, Cambridge, CB2 2QQ, UK.
3
Department of Pharmacology, University of Bergen,
Armauer Hansens Hus, 5021 Bergen, Norway.
4
Medical Statistics Unit, London School of Hygiene &
Tropical Medicine, Keppel St., London, UK.
a Author for correspondence. Fax (44)1865-558817; e-mail robert.clarke{at}ctsu.ox.ac.uk.
The variability of plasma total homocysteine (tHcy) was examined in 96 individuals over a 1-yr period. Blood tHcy concentrations varied from 7.1 µmol/L in the bottom quintile to 14.5 µmol/L in the top quintile. The mean tHcy was 10.4 µmol/L, the between-person SD was 2.5 µmol/L, and the within-person SD was 0.93 µmol/L. There was little seasonal variation, and the reliability coefficient was 0.88. Mean tHcy concentrations were inversely related to mean plasma folate (r = -0.36) and vitamin B12 (r = -0.35) concentrations. Median tHcy concentrations were ~1 µmol/L higher in men than in women and in older (70 to 74 years) than in younger (65 to 69 years) individuals and higher in those with the TT and CT genotypes for the methylenetetrahydrofolate reductase polymorphism than in those with the CC genotype (10.7 and 10.6 vs 9.6 µmol/L). Epidemiological studies based on single tHcy measurements may underestimate the magnitude of any risk associations with disease by 10–15%.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  R. R. McLean, P. F. Jacques, J. Selhub, L. Fredman, K. L. Tucker, E. J. Samelson, D. P. Kiel, L. A. Cupples, and M. T. Hannan Plasma B Vitamins, Homocysteine, and Their Relation with Bone Loss and Hip Fracture in Elderly Men and Women J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2206 - 2212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Dangour, E. Breeze, R. Clarke, P. S. Shetty, R. Uauy, and A. E. Fletcher Plasma Homocysteine, but Not Folate or Vitamin B-12, Predicts Mortality in Older People in the United Kingdom J. Nutr., June 1, 2008; 138(6): 1121 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zoccolella, I. L. Simone, P. Lamberti, V. Samarelli, R. Tortelli, L. Serlenga, and G. Logroscino Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis Neurology, January 15, 2008; 70(3): 222 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soumare, A. Elbaz, V. Ducros, B. Tavernier, A. Alperovitch, and C. Tzourio Cross-sectional association between homocysteine and motor function in the elderly. Neurology, September 26, 2006; 67(6): 985 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Irizarry, M. E. Gurol, S. Raju, R. Diaz-Arrastia, J. J. Locascio, M. Tennis, B. T. Hyman, J. H. Growdon, S. M. Greenberg, and T. Bottiglieri Association of homocysteine with plasma amyloid {beta} protein in aging and neurodegenerative disease Neurology, November 8, 2005; 65(9): 1402 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Solomon Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing Blood, February 1, 2005; 105(3): 978 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nurk, G. S Tell, S. E Vollset, O. Nygard, H. Refsum, R. M Nilsen, and P. M Ueland Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study Am. J. Clinical Nutrition, May 1, 2004; 79(5): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Huijgen, F. P.W. Tegelaers, C. H.H. Schoenmakers, C. J. Pronk-Admiraal, and S. Ekema Multicenter Analytical Evaluation of an Enzymatic Method for the Measurement of Plasma Homocysteine and Comparison with HPLC and Immunochemistry Clin. Chem., May 1, 2004; 50(5): 937 - 940. [Full Text] [PDF]
|
|
|
|
|
|
H. Refsum, A. D. Smith, P. M. Ueland, E. Nexo, R. Clarke, J. McPartlin, C. Johnston, F. Engbaek, J. Schneede, C. McPartlin, et al. Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion Clin. Chem., January 1, 2004; 50(1): 3 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McCaddon, P. Hudson, C. McCracken, R. Ellis, and A. McCaddon Biological Variation of Holo-Transcobalamin in Elderly Individuals Clin. Chem., September 1, 2003; 49(9): 1542 - 1544. [Full Text] [PDF]
|
|
|
|
|
|
M. R. Fokkema, M. F. Gilissen, J. J. van Doormaal, M. Volmer, I. P. Kema, and F. A.J. Muskiet Fasting vs Nonfasting Plasma Homocysteine Concentrations for Diagnosis of Hyperhomocysteinemia Clin. Chem., May 1, 2003; 49(5): 818 - 821. [Full Text] [PDF]
|
|
|
|
|
|
L. El-Khairy, S. E. Vollset, H. Refsum, and P. M. Ueland Predictors of Change in Plasma Total Cysteine: Longitudinal Findings from the Hordaland Homocysteine Study Clin. Chem., January 1, 2003; 49(1): 113 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Lim and P. A. Cassano Homocysteine and Blood Pressure in the Third National Health and Nutrition Examination Survey, 1988-1994 Am. J. Epidemiol., December 15, 2002; 156(12): 1105 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.D. Prins, T. den Heijer, A. Hofman, P.J. Koudstaal, J. Jolles, R. Clarke, and M.M.B. Breteler Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study Neurology, November 12, 2002; 59(9): 1375 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nurk, G. S. Tell, S. E. Vollset, O. Nygard, H. Refsum, and P. M. Ueland Plasma Total Homocysteine and Hospitalizations for Cardiovascular Disease: The Hordaland Homocysteine Study Arch Intern Med, June 24, 2002; 162(12): 1374 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Voortman, A. Melse-Boonstra, J. M. Schulz, J. Burema, M. B. Katan, and P. Verhoef Optimal Time Interval between Repeated Blood Sampling for Measurements of Total Homocysteine in Healthy Individuals Clin. Chem., October 1, 2001; 47(10): 1839 - 1841. [Full Text] [PDF]
|
|
|
|
|
|
M. C. McKinley, J.J. Strain, J. McPartlin, J. M. Scott, and H. McNulty Plasma Homocysteine Is Not Subject to Seasonal Variation Clin. Chem., August 1, 2001; 47(8): 1430 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Wald, L. Bishop, N. J. Wald, M. Law, E. Hennessy, D. Weir, J. McPartlin, and J. Scott Randomized Trial of Folic Acid Supplementation and Serum Homocysteine Levels Arch Intern Med, March 12, 2001; 161(5): 695 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. de Jong, M. J. C. A Paw, L. C. de Groot, R. A. Rutten, D. W Swinkels, F. J Kok, and W. A van Staveren Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning Am. J. Clinical Nutrition, February 1, 2001; 73(2): 338 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Devlin, E.-h. Ling, J. M. Peerson, S. Fernando, R. Clarke, A. D. Smith, and C. H. Halsted Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia Hum. Mol. Genet., November 1, 2000; 9(19): 2837 - 2844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Essama-Tjani, J.-C. Guilland, G. Potier de Courcy, F. Fuchs, and D. Richard Folate Status Worsens in Recently Institutionalized Elderly People without Evidence of Functional Deterioration J. Am. Coll. Nutr., June 1, 2000; 19(3): 392 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Vollset, H. Refsum, L. M Irgens, B. M. Emblem, A. Tverdal, H. K Gjessing, A. L. B. Monsen, and P. M. Ueland Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study Am. J. Clinical Nutrition, April 1, 2000; 71(4): 962 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. BUDGE, C. JOHNSTON, E. HOGERVORST, C. DE JAGER, E. MILWAIN, S. D. IVERSEN, L. BARNETSON, M. BUDGE, E. KING, and A. D. SMITH Plasma Total Homocysteine and Cognitive Performance in a Volunteer Elderly Population Ann. N.Y. Acad. Sci., April 1, 2000; 903(1): 407 - 410. [Full Text] [PDF]
|
|
|
|
|
|
R. CLARKE, C. JOACHIM, M. ESIRI, J. MORRIS, H. BUNGAY, A. MOLYNEUX, M. BUDGE, C. FROST, E. KING, L. BARNETSON, et al. Leukoaraiosis at Presentation and Disease Progression during Follow-up in Histologically Confirmed Cases of Dementia Ann. N.Y. Acad. Sci., April 1, 2000; 903(1): 497 - 500. [Full Text] [PDF]
|
|
|
|
|
|
R. Carmel, R. Green, D. W Jacobsen, K. Rasmussen, M. Florea, and C. Azen Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities Am. J. Clinical Nutrition, November 1, 1999; 70(5): 904 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rasmussen, J. Moller, and M. Lyngbak Within-Person Variation of Plasma Homocysteine and Effects of Posture and Tourniquet Application Clin. Chem., October 1, 1999; 45(10): 1850 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Moller, K. Rasmussen, and L. Christensen External Quality Assessment of Methylmalonic Acid and Total Homocysteine Clin. Chem., September 1, 1999; 45(9): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thirup and S. Ekelund Day-to-Day, Postprandial, and Orthostatic Variation of Total Plasma Homocysteine Clin. Chem., August 1, 1999; 45(8): 1280 - 1283. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Clarke, A. D. Smith, K. A. Jobst, H. Refsum, L. Sutton, and P. M. Ueland Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease Arch Neurol, November 1, 1998; 55(11): 1449 - 1455. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
