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Clinical Chemistry 44: 141-147, 1998;
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(Clinical Chemistry. 1998;44:141-147.)
© 1998 American Association for Clinical Chemistry, Inc.

Drug Monitoring and Toxicology

Study of arsenic–protein binding in serum of patients on continuous ambulatory peritoneal dialysis

Xinrong Zhang1, Rita Cornelis1,a, Jurgen De Kimpe1, Louis Mees1, and Norbert Lameire2

1 Laboratory for Analytical Chemistry, Institute for Nuclear Sciences, University of Gent, Proeftuinstr. 86, B-9000 Gent, Belgium.

2 Renal Division, Department of Medicine, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium.
a Author for correspondence. Fax 32 (0)9 2646699;

Arsenic (As) bound to serum proteins in patients on continuous ambulatory peritoneal dialysis (CAPD) was studied. A prior experiment by ultrafiltration showed that 5.57% of total As was bound to serum proteins for 14 CAPD patients. Further identification of the As species and protein molecules in serum of three CAPD patients with high As concentrations was carried out by combining the separation methods of size-exclusion, anion-exchange, and affinity fast-protein liquid chromatography, detected by hydride generation atomic absorption spectrometry. The results indicated that only inorganic As species are bound to serum proteins. Transferrin is the main carrier. The concentrations of As bound to proteins in serum for the three patients were 0.44 ± 0.12, 0.19 ± 0.09, and 0.59 ± 0.09 µg/L (n = 3), respectively.




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D. Douer and M. S. Tallman
Arsenic Trioxide: New Clinical Experience With an Old Medication in Hematologic Malignancies
J. Clin. Oncol., April 1, 2005; 23(10): 2396 - 2410.
[Abstract] [Full Text] [PDF]


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