Increased oxidative stress in dilated cardiomyopathic heart failure

Doan Yücel^1,a, Sinan Aydodu², Sengül Çehreli², Gülsevim Saydam¹, Hayrettin Canatan¹, Mehmet ene¹, Birsen Çidem Topkaya¹, and Serpil Nebiolu³

¹ Biochemistry Laboratory and
² Department of Cardiology, High Specialization Hospital (Yüksek htisas Hastanesi), Sihhiye, Ankara 06100, Turkey.

³ Department of Biochemistry, Institute of Health Sciences, Ankara University, Ankara, Turkey.
^a Author for correspondence.

In the present study, we assessed oxidative stress in patients with dilated cardiomyopathy of ischemic or idiopathic etiology. For this reason we measured whole blood reduced glutathione, erythrocyte superoxide dismutase, susceptibility of erythrocyte membranes and erythrocytes to peroxidation, and SH content of erythrocyte membranes in 12 patients (8 men and 4 women, ages 31 to 66 years) with idiopathic dilated cardiomyopathy, in 11 patients (8 men and 3 women, ages 32 to 65 years) with ischemic dilated cardiomyopathy, and in 21 healthy volunteers (12 men and 9 women, ages 25 to 67 years). There was no statistically significant difference between the two patient groups for the indicators studied (P >0.05). Blood glutathione, erythrocyte superoxide dismutase, and membrane SH content of both groups of patients was decreased compared with controls (P <0.05), whereas erythrocyte and membrane susceptibility to peroxidation were increased (P <0.05). We conclude that patients with idiopathic or ischemic dilated cardiomyopathy exhibit abnormalities of a range of markers of increased oxidative stress. These abnormalities may contribute to contractile dysfunction, increased incidence of fatal arrhythmias, and sudden death.

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