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Enzymes and Protein Markers |
1
R&D Systems, Inc., 614 McKinley Place NE, Minneapolis, MN 55413.
2
State University of New York Health Science Center
at Brooklyn, Brooklyn, NY.
3
University of Cincinnati Medical Center,
Cincinnati, OH.
4
VA Medical Center, Minneapolis, MN.
5
University of Colorado Health Sciences Center,
Denver, CO.
a Author for correspondence. Fax 612/379-6580; e-mail tomd{at}rndsystems.com.
The concentration of soluble transferrin receptor (sTfR) in serum is reported to be useful in the diagnosis of iron deficiency, especially for patients with concurrent chronic disease, where routine tests of iron status are compromised by the inflammatory condition. A new diagnostic assay for sTfR is calibrated against natural plasma sTfR, thus minimizing calibration discrepancies that result from differences between the analyte and the cellular transferrin receptor used in other assays. Use of the new assay to measure sTfR concentrations in 225 healthy, hematologically normal adults provided a reference interval against which pathological samples could be compared. There was no difference in the reference intervals for men and women and no correlation of [sTfR] with the age of the subject. Black subjects had significantly higher concentrations than nonblacks, and people living at high altitude had higher concentrations than those living closer to sea level. These differences were additive.
The following articles in journals at HighWire Press have cited this article:
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  C. A Northrop-Clewes Interpreting indicators of iron status during an acute phase response - lessons from malaria and human immunodeficiency virus Ann Clin Biochem, January 1, 2008; 45(1): 18 - 32. [Abstract] [Full Text] [PDF]
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 S. A. Holme, M. Worwood, A. V. Anstey, G. H. Elder, and M. N. Badminton Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria Blood, December 1, 2007; 110(12): 4108 - 4110. [Abstract] [Full Text] [PDF]
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 H. Knox-Macaulay, D. Gravell, and F. Elender Serum Transferrin Receptor Status of Healthy Adult Arabs Ann. Clin. Lab. Sci., January 1, 2007; 37(1): 57 - 62. [Abstract] [Full Text] [PDF]
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 A. T. Chan, J. Ma, G. J. Tranah, E. L. Giovannucci, N. Rifai, D. J. Hunter, and C. S. Fuchs Hemochromatosis Gene Mutations, Body Iron Stores, Dietary Iron, and Risk of Colorectal Adenoma in Women J Natl Cancer Inst, June 15, 2005; 97(12): 917 - 926. [Abstract] [Full Text] [PDF]
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 M. B Zimmermann, L. Molinari, F. Staubli-Asobayire, S. Y Hess, N. Chaouki, P. Adou, and R. F Hurrell Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children Am. J. Clinical Nutrition, March 1, 2005; 81(3): 615 - 623. [Abstract] [Full Text] [PDF]
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 T. W. McDade and B. Shell-Duncan Whole Blood Collected on Filter Paper Provides a Minimally Invasive Method for Assessing Human Transferrin Receptor Level J. Nutr., December 1, 2002; 132(12): 3760 - 3763. [Abstract] [Full Text] [PDF]
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 G. Van den Bosch, J. Van den Bossche, C. Wagner, P. De Schouwer, M. Van De Vyvere, and H. Neels Determination of Iron Metabolism-related Reference Values in a Healthy Adult Population Clin. Chem., August 1, 2001; 47(8): 1465 - 1467. [Full Text] [PDF]
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J. W. Choi, S. H. Pai, M. W. Im, and S. K. Kim Change in Transferrin Receptor Concentrations with Age Clin. Chem., September 1, 1999; 45(9): 1562 - 1563. [Full Text] [PDF]
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P. Suominen, K. Punnonen, A. Rajamaki, R. Majuri, V. Hanninen, and K. Irjala Automated Immunoturbidimetric Method for Measuring Serum Transferrin Receptor Clin. Chem., August 1, 1999; 45(8): 1302 - 1305. [Full Text] [PDF]
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B. S. Skikne Circulating Transferrin Receptor Assay—Coming of Age Clin. Chem., January 1, 1998; 44(1): 7 - 9. [Full Text] [PDF]
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