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Enzymes and Protein Markers |
Departments of
1
Medicine and
2
Chemical Pathology, University of Zimbabwe Medical School, Box A178 Avondale, Harare, Zimbabwe.
3
National Institute of Child Health and Human
Development, Cell Biology and Metabolism Branch, Bldg. 18T, Rm. 101,
Bethesda, MD 20892.
4
Division of Hematology and Oncology, Department of
Medicine, The George Washington University Medical Center, 2150
Pennsylvania Ave., NW, Suite 3-428, Washington, DC 20037.
a Author for correspondence. Fax 263-4-720640; e-mail ceu{at}healthnet.zim.
To test the hypothesis that the quantities of circulating transferrin
receptors are reduced in iron overload, we studied serum transferrin
receptors and indirect measures of iron status in 150 subjects from
rural Zimbabwe. We found significant inverse correlations between serum
concentrations of transferrin receptors and ferritin, the ratio of
ferritin to aspartate aminotransferase, and transferrin saturation
(r 
0.44; P <0.001). The mean ± SD
concentration of serum transferrin receptors in 23 subjects classified
as having iron overload (ferritin >300 µg/L and transferrin
saturation >60%) was 1.55 ± 0.61 mg/L, significantly lower than
the 2.50 ± 0.62 mg/L in 75 subjects with normal iron stores
(ferritin 20–300 µg/L and transferrin saturation 15–55%;
P <0.0005) and the 2.83 ± 1.14 mg/L in 8 subjects
with iron deficiency (ferritin <20 µg/L; P =
0.001). In keeping with the regulation of transferrin receptor
expression at the cellular level, our findings suggest that serum
transferrin receptors are decreased in the presence of iron
overload.
The following articles in journals at HighWire Press have cited this article:
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  J. M McDermid, M. F S. van der Loeff, A. Jaye, B. J Hennig, C. Bates, J. Todd, G. Sirugo, A. V Hill, H. C Whittle, and A. M Prentice Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction Am. J. Clinical Nutrition, July 1, 2009; 90(1): 225 - 233. [Abstract] [Full Text] [PDF]
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 P. Halonen, J. Mattila, P. Suominen, T. Ruuska, M. K. Salo, and A. Makipernaa Iron Overload in Children Who Are Treated for Acute Lymphoblastic Leukemia Estimated by Liver Siderosis and Serum Iron Parameters Pediatrics, January 1, 2003; 111(1): 91 - 96. [Abstract] [Full Text] [PDF]
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 I. Kasvosve, J. R. Delanghe, Z. A.R. Gomo, I. T. Gangaidzo, H. Khumalo, B. Wuyts, E. Mvundura, T. Saungweme, V. M. Moyo, J. R. Boelaert, et al. Transferrin Polymorphism Influences Iron Status in Blacks Clin. Chem., October 1, 2000; 46(10): 1535 - 1539. [Abstract] [Full Text] [PDF]
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M. R. Langlois, M.-E. Martin, J. R. Boelaert, C. Beaumont, Y. E. Taes, M. L. De Buyzere, D. R. Bernard, H. M. Neels, and J. R. Delanghe The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males Clin. Chem., October 1, 2000; 46(10): 1619 - 1625. [Abstract] [Full Text] [PDF]
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A. C. Looker, M. Loyevsky, and V. R. Gordeuk Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration Clin. Chem., December 1, 1999; 45(12): 2191 - 2199. [Abstract] [Full Text] [PDF]
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B. S. Skikne Circulating Transferrin Receptor Assay—Coming of Age Clin. Chem., January 1, 1998; 44(1): 7 - 9. [Full Text] [PDF]
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