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Clinical Chemistry 44: 40-44, 1998;
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(Clinical Chemistry. 1998;44:40-44.)
© 1998 American Association for Clinical Chemistry, Inc.

Enzymes and Protein Markers

Serum transferrin receptors are decreased in the presence of iron overload

Hlosukwazi Khumalo1, Zvenyika A. R. Gomo2,a, Victor M. Moyo1, Victor R. Gordeuk4, Thokozile Saungweme1, Tracey A. Rouault3, and Innocent T. Gangaidzo1

Departments of
1 Medicine and
2 Chemical Pathology, University of Zimbabwe Medical School, Box A178 Avondale, Harare, Zimbabwe.
3 National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch, Bldg. 18T, Rm. 101, Bethesda, MD 20892.

4 Division of Hematology and Oncology, Department of Medicine, The George Washington University Medical Center, 2150 Pennsylvania Ave., NW, Suite 3-428, Washington, DC 20037.
a Author for correspondence. Fax 263-4-720640; e-mail ceu{at}healthnet.zim.

To test the hypothesis that the quantities of circulating transferrin receptors are reduced in iron overload, we studied serum transferrin receptors and indirect measures of iron status in 150 subjects from rural Zimbabwe. We found significant inverse correlations between serum concentrations of transferrin receptors and ferritin, the ratio of ferritin to aspartate aminotransferase, and transferrin saturation (r >=0.44; P <0.001). The mean ± SD concentration of serum transferrin receptors in 23 subjects classified as having iron overload (ferritin >300 µg/L and transferrin saturation >60%) was 1.55 ± 0.61 mg/L, significantly lower than the 2.50 ± 0.62 mg/L in 75 subjects with normal iron stores (ferritin 20–300 µg/L and transferrin saturation 15–55%; P <0.0005) and the 2.83 ± 1.14 mg/L in 8 subjects with iron deficiency (ferritin <20 µg/L; P = 0.001). In keeping with the regulation of transferrin receptor expression at the cellular level, our findings suggest that serum transferrin receptors are decreased in the presence of iron overload.




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