Clinical Chemistry
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Clinical Chemistry 44: 96-101, 1998;
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(Clinical Chemistry. 1998;44:96-101.)
© 1998 American Association for Clinical Chemistry, Inc.

Hematology

Hematological indices in an older population sample: derivation of healthy reference values

Chiu Wah Tsang1, Ross Lazarus1,a, Wayne Smith5, Paul Mitchell2, Jerry Koutts3, and Leslie Burnett4,6

Departments of
1 Public Health and Community Medicine,
2 Ophthalmology,
3 Medicine, and
4 Pathology, University of Sydney, Sydney, NSW 2006, Australia.
5 National Centre for Epidemiology and Population Health, Australian National University, GPO 4, Canberra, ACT 2601, Australia.

6 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia.
a Address correspondence to this author at: Public Health and Community Medicine, Westmead Hospital, Westmead, NSW 2145, Australia. Fax 61 2 689 1049; e-mail rossl{at}pub.health.su.oz.au.

Factors affecting hematological values were explored, and healthy reference values were estimated from a cross-sectional survey of a population (n = 4433), ages 49 years or more, residing permanently in a defined geographic region. Nursing home residents were excluded. Details of medication use and medical history were obtained by interview, and participants were asked to return after an overnight fast for blood sampling. The participation rate was 82.4%, of whom 88.4% provided a fasting blood sample. Hemoglobin, hematocrit, and erythrocyte counts were higher in men, whereas platelet counts were higher in women. Statistical associations between each hematological index and smoking, alcohol intake, use of certain drugs, chronic disease, and high creatinine values were tested by unpaired t-tests. Separate reference groups were defined for each hematological index by excluding subjects with any of the factors found to be of importance. The resulting reference values are particularly appropriate for evaluating hematological test results in older individuals.




The following articles in journals at HighWire Press have cited this article:


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T. I. Takala, P. Suominen, R. Isoaho, S.-L. Kivela, M. Lopponen, O. Peltola, A. Rajamaki, and K. Irjala
Iron-Replete Reference Intervals to Increase Sensitivity of Hematologic and Iron Status Laboratory Tests in the Elderly
Clin. Chem., September 1, 2002; 48(9): 1586 - 1589.
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