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Clinical Chemistry 44: 2120-2125, 1998;
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(Clinical Chemistry. 1998;44:2120-2125.)
© 1998 American Association for Clinical Chemistry, Inc.

Enzymes and Protein Markers

Intra- and interindividual variability of carbohydrate-deficient transferrin, {gamma}-glutamyltransferase, and mean corpuscular volume in teetotalers

Anders Helander1,a, Erling Vabö1, Klas Levin2, and Stefan Borg1

1 Department of Clinical Neuroscience, Karolinska Institute, Center for Dependency Disorders at St. Görans & Karolinska Hospital, S-10229 Stockholm, Sweden.

2 Nova Medical Calab, St. Görans Hospital, S-11281 Stockholm, Sweden.
a Address correspondence to this author at: Alcohol & Drug Dependence Unit, St. Görans Hospital, S-11281 Stockholm, Sweden. Fax 46-8-6721994; e-mail anders.helander{at}bekl.csso.sll.se.

Blood samples for determination of the biochemical alcohol markers carbohydrate-deficient transferrin (CDT) in serum, {gamma}-glutamyltransferase (GGT) in serum, and erythrocyte mean corpuscular volume (MCV) were collected once every 1–2 weeks over ~5 months from 10 female and 4 male teetotalers. Mean values for serum CDT (using the CDTectTM assay) ranged from 9.9 to 29.4 units/L (median, 14.2 units/L), and the highest results were obtained in the women. The mean values for serum GGT ranged from 0.15 to 0.49 µkat/L (median, 0.30 µkat/L, or 18 U/L) except for one woman with a very high mean of 3.07 µkat/L. For MCV, the mean values ranged from 79.5 to 91.5 fL. Two women showed several CDT results above the upper reference limit (mean values, 27.6 and 29.4 units/L, respectively); however, their GGT and MCV values fell within the reference intervals. One of these women exhibited an increased total transferrin concentration (mean value, 5.38 g/L), which was possibly related to the use of oral contraceptives and/or a low serum iron concentration. When the CDTect value was expressed relative to total transferrin, a ratio within the reference interval was observed for this woman but not for the other woman with increased CDTect values. The present study demonstrates a considerable variation between individuals in CDT, GGT, and MCV without drinking any alcohol. The results also show that these baseline values are fairly constant over time within the same individual.




The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
A. Helander, G. Eriksson, H. Stibler, and J.-O. Jeppsson
Interference of Transferrin Isoform Types with Carbohydrate-deficient Transferrin Quantification in the Identification of Alcohol Abuse
Clin. Chem., July 1, 2001; 47(7): 1225 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Arndt
Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and Interpretation
Clin. Chem., January 1, 2001; 47(1): 13 - 27.
[Abstract] [Full Text] [PDF]

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 J. Neurol. Neurosurg. PsychiatryHome page
G. Brathen, K. S Bjerve, E. Brodtkorb, and G. Bovim
Validity of carbohydrate deficient transferrin and other markers as diagnostic aids in the detection of alcohol related seizures
J. Neurol. Neurosurg. Psychiatry, March 1, 2000; 68(3): 342 - 348.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Helander
Absolute or Relative Measurement of Carbohydrate-deficient Transferrin in Serum? Experiences with Three Immunological Assays
Clin. Chem., January 1, 1999; 45(1): 131 - 135.
[Full Text] [PDF]


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