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Clinical Chemistry 44: 2270-2276, 1998;
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Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 1998;44:2270-2276.)
© 1998 American Association for Clinical Chemistry, Inc.

Enzymes and Protein Markers

Cardiac troponin I and minor cardiac damage: biochemical markers in a clinical model of myocardial lesions

José Manuel del Rey1, Antonio Hernández Madrid2, José Manuel Valiño1, José Rubí1, José Mercader1, Concepción Moro2,a, and Eduardo Ripoll1

1 Clinical Biochemistry Department and
2 Arrhythmia Unit, Ramón y Cajal Hospital, Department of Medicine, Alcalá University, 28034 Madrid, Spain.
a Address correspondence to this author at: Arrhythmia Unit, Ramón y Cajal Hospital, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain. Fax 91-3368183; e-mail concepcion.moro{at}hrc.es.

Radiofrequency (RF) catheter ablation is the curative treatment of choice for many cardiac arrhythmias. After RF ablation there is always a small localized endomyocardial necrosis, necessary to abolish the arrhythmia. We designed this study to determine the serum concentrations of several cardiac markers in patients who underwent RF catheter ablation. The study shows a higher frequency of increase of serum cardiac troponin I (cTnI) than of creatine kinase (CK), the CK MB isoenzyme (CK-MB), or myoglobin. A pathological value of cTnI was found in 47 of 51 patients (92%) in the ablation group. The area under the ROC curve for cTnI was 0.9375, significantly higher than for the other biochemical markers (0.86, 0.76, and 0.75 for CK-MB, myoglobin, and CK, respectively), with P <0.05. We conclude that the serum concentration of cTnI is the best biochemical marker for detecting the minor myocardial damage produced by RF ablation.




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